Source:http://linkedlifedata.com/resource/pubmed/id/20034802
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2010-2-9
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| pubmed:abstractText |
The reaction of betulinic aldehydes with various carbon nucleophiles gave a series of new betulin derivatives, among them epoxides, glycidic derivatives and beta-hydroxy carbonyl compounds. Subsequent transformations of the beta-hydroxy carbonyls lead to 1,3-diketo- and alpha,beta-unsaturated betulin derivatives. These compounds were assayed for cytotoxicity using 15 human cancer cell lines and a colorimetric SRB-assay. Several compounds revealed significant antitumour activity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
|
| pubmed:issn |
1464-3391
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
18
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1344-55
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| pubmed:meshHeading |
pubmed-meshheading:20034802-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:20034802-Apoptosis,
pubmed-meshheading:20034802-Cell Line, Tumor,
pubmed-meshheading:20034802-Drug Screening Assays, Antitumor,
pubmed-meshheading:20034802-Humans,
pubmed-meshheading:20034802-Inhibitory Concentration 50,
pubmed-meshheading:20034802-Molecular Structure,
pubmed-meshheading:20034802-Neoplasms,
pubmed-meshheading:20034802-Structure-Activity Relationship,
pubmed-meshheading:20034802-Triterpenes
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| pubmed:year |
2010
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| pubmed:articleTitle |
Synthesis and biological evaluation of antitumour-active betulin derivatives.
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| pubmed:affiliation |
Bereich Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str 2, D-06120 Halle, Saale, Germany. rene.csuk@chemie.uni-halle.de
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| pubmed:publicationType |
Journal Article
|