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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-4-14
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pubmed:abstractText |
Insulin transport across the epithelial cell layer in the small intestine was studied using insulin/transferrin conjugates with and without the presence of P(MAA-g-EG) microparticles in contact with a co-culture of Caco-2/HT29-MTX cells. The insulin/transferrin conjugate was shown to increase transport relative to pure insulin by a factor of 7, achieving an apparent permeability of 37 x 10(9) cm . s(-1). The presence of P(MAA-g-EG) microparticles increased conjugate transport by a factor of 14 times relative to insulin, achieving an apparent permeability of 72.8 x 10(9) cm . s(-1). The presence of the microparticles in solution was found to improve conjugate transport by nearly 100% with little to no change in cell monolayer integrity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-10503971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-15093592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-15147809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-15749282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-16368228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-16529810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-16631271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-708370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-7816770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-8440376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-8842358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-8897273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-9453050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20034125-9811489
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1616-5195
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-306
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20034125-Administration, Oral,
pubmed-meshheading:20034125-Caco-2 Cells,
pubmed-meshheading:20034125-Cell Membrane Permeability,
pubmed-meshheading:20034125-Cell-Derived Microparticles,
pubmed-meshheading:20034125-Coculture Techniques,
pubmed-meshheading:20034125-Drug Delivery Systems,
pubmed-meshheading:20034125-Electric Impedance,
pubmed-meshheading:20034125-Epithelial Cells,
pubmed-meshheading:20034125-HT29 Cells,
pubmed-meshheading:20034125-Humans,
pubmed-meshheading:20034125-Hydrogels,
pubmed-meshheading:20034125-Insulin,
pubmed-meshheading:20034125-Polyethylene Glycols,
pubmed-meshheading:20034125-Polymethacrylic Acids,
pubmed-meshheading:20034125-Protein Transport,
pubmed-meshheading:20034125-Solutions,
pubmed-meshheading:20034125-Transferrin
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pubmed:year |
2010
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pubmed:articleTitle |
Cellular evaluation of synthesized insulin/transferrin bioconjugates for oral insulin delivery using intelligent complexation hydrogels.
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pubmed:affiliation |
Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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