Source:http://linkedlifedata.com/resource/pubmed/id/20034048
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2009-12-29
|
| pubmed:abstractText |
Human leukocyte antigen B27 (HLA-B27) is associated with protection in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection. This protective role is linked to single immunodominant HLA-B27-restricted CD8+ T-cell epitopes in both infections. In order to define the relative contribution of a specific HLA-B27-restricted epitope to the natural course of HCV infection, we compared the biological impact of the highly conserved HCV genotype 1 epitope, for which the protective role has been described, with the corresponding region in genotype 3 that differs in its sequence by three amino acid residues. The genotype 3a peptide was not recognized by CD8+ T cells specific for the genotype 1 peptide. Furthermore, patients with acute or chronic infection with HCV genotype 3a did not mount T-cell responses to this epitope region, and their autologous viral sequences showed no evidence of T-cell pressure. Finally, we found a significantly higher frequency of HLA-B27 positivity in patients with chronic HCV genotype 3a infection compared to genotype 1 infection, indicating that there is no protection by HLA-B27 in HCV genotype 3 infection. CONCLUSION: Our data indicate that the protective effect of HLA-B27 is limited to HCV genotype 1 infection and does not expand to other genotypes such as genotype 3a. This can most likely be explained by intergenotype sequence diversity leading to the loss of the immunodominant HLA-B27 epitope in viral strains other than genotype 1. Our results underline the central role of a single HLA-B27-restricted epitope-specific CD8+ T-cell response in mediating protection in HCV genotype 1 infection.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1527-3350
|
| pubmed:author |
pubmed-author:AllenTodd MTM,
pubmed-author:BarnesEleanorE,
pubmed-author:BlumHubert EHE,
pubmed-author:BownessPaulP,
pubmed-author:FitzmauriceKarenK,
pubmed-author:HumphreysIslaI,
pubmed-author:HuzlyDanielaD,
pubmed-author:KelleherDermotD,
pubmed-author:KemperMichael NMN,
pubmed-author:KerstingNadineN,
pubmed-author:KimArthur YAY,
pubmed-author:LauerGeorg MGM,
pubmed-author:LohmannVolkerV,
pubmed-author:McKiernanSusanS,
pubmed-author:Neumann-HaefelinChristophC,
pubmed-author:Oniangue-NdzaCesarC,
pubmed-author:RoggendorfMichaelM,
pubmed-author:RosenHugo RHR,
pubmed-author:SchmidtJuliaJ,
pubmed-author:ThimmeRobertR,
pubmed-author:TimmJörgJ
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
54-62
|
| pubmed:meshHeading |
pubmed-meshheading:20034048-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20034048-Epitopes, T-Lymphocyte,
pubmed-meshheading:20034048-HLA-B27 Antigen,
pubmed-meshheading:20034048-Hepacivirus,
pubmed-meshheading:20034048-Hepatitis C,
pubmed-meshheading:20034048-Humans,
pubmed-meshheading:20034048-Immunodominant Epitopes
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope.
|
| pubmed:affiliation |
Department of Medicine II, University of Freiburg, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|