Linked Life Data

20033867

Source:http://linkedlifedata.com/resource/pubmed/id/20033867

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-5-26
pubmed:abstractText
Combinations of crude rhizomes of Coptis chinensis Franch., Ranunculaceae, and fruits of Evodia rutaecarpa (Juss.) Benth., Rutaceae, at a ratio of 6 : 1 (formula A) and 1 : 6 (formula B) were extracted with boiling water, and their modulatory activity on enteric mucosal immune responses in mice with dextran sulphate sodium-induced ulcerative colitis was investigated. The results showed that both formulas could reduce the severity of inflammation in the colon. Formula A at a low dose can decrease myeloperoxidase (MPO) activity, and formula B was inactive. Both formulas did not affect the percentages of CD4 (+) and CD8 (+) T cells in the periphery, but they evoked an increase of CD8 (+) T cells among the enteric intraepithelial lymphocytes. Formula B at a low dose could increase both CD4 (+) and CD8 (+) cells, and formula A at a high dose could only increase CD8 (+) T cells among the Peyer's patch lymphocytes (p < 0.05). Both formulas did not affect the percentages of CD4 (+) and CD8 (+) T cells among the lamina propria lymphocytes, but decreased the serum concentration of IL-1 beta (p < 0.05 at a low dose of formula A) and enhanced the level of IL-10 in serum (p < 0.05 at a low dose formula B). We conclude that both formulas have a similar modulating effect on enteric mucosal immune responses, the major difference being that formula A could decrease the level of IL-1 beta, while formula B could increase the IL-10 dose in serum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1439-0221
pubmed:author
pubmed:copyrightInfo
Georg Thieme Verlag KG Stuttgart New York.
pubmed:issnType
Electronic
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
766-72
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Comparison of the enteric mucosal immunomodulatory activity of combinations of Coptis chinensis Franch. Rhizomes and Evodia rutaecarpa (Juss.) Benth. Fruits in mice with dextran sulphate sodium-induced ulcerative colitis.
pubmed:affiliation
Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, PR China.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't