Source:http://linkedlifedata.com/resource/pubmed/id/20033742
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2010-2-22
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| pubmed:abstractText |
Alterations in brain-derived neurotrophic factor (BDNF)-signaling pathways may play an important role in the pathophysiology of major depressive disorder (MDD). Several lines of evidence have suggested that gene-gene interactions may confer susceptibility to MDD. The aim of this study was to analyze the single and combined effects of genes in the BDNF signal-transduction pathway on MDD in a Chinese population. We recruited 447 patients with MDD and 432 age- and gender-matched control subjects. Five SNPs in three BDNF signal-transduction pathway genes (BDNF, GSK3B and AKT1) were used in association analyses. An allelic association between the GSK3B SNP rs6782799 and MDD was found in our sample (allelic: chi(2) = 5.24, P = 0.022, corrected P = 0.107; genotypic: chi(2) = 5.55, P = 0.062) with an odds ratio (OR) of 1.25 (95% confidence interval (CI) 1.03-1.52). Further gene-gene interaction analyses showed a significant effect of a two-locus BDNF/GSK3B interaction with MDD (GSK3B rs6782799 and BDNF rs7124442) (corrected P = 0.011), and also for a three-locus interaction (GSK3B rs6782799, BDNF rs6265 and BDNF rs7124442) (corrected P = 0.019). Individuals carrying the combination of two risk alleles showed an OR value of 4.00 (95% CI 2.05-7.79), while those with the combination of three risk alleles gave the largest OR value of 4.46 (95% CI 2.15-9.24). Taken together, these findings support the assertion that the GSK3B gene is an important susceptibility factor for MDD in a Han Chinese population.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1435-1463
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
117
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
393-401
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| pubmed:dateRevised |
2011-11-2
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| pubmed:meshHeading |
pubmed-meshheading:20033742-Adolescent,
pubmed-meshheading:20033742-Adult,
pubmed-meshheading:20033742-Asian Continental Ancestry Group,
pubmed-meshheading:20033742-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:20033742-China,
pubmed-meshheading:20033742-Depressive Disorder, Major,
pubmed-meshheading:20033742-Female,
pubmed-meshheading:20033742-Gene Frequency,
pubmed-meshheading:20033742-Genetic Association Studies,
pubmed-meshheading:20033742-Genetic Predisposition to Disease,
pubmed-meshheading:20033742-Genotype,
pubmed-meshheading:20033742-Glycogen Synthase Kinase 3,
pubmed-meshheading:20033742-Humans,
pubmed-meshheading:20033742-Linkage Disequilibrium,
pubmed-meshheading:20033742-Male,
pubmed-meshheading:20033742-Middle Aged,
pubmed-meshheading:20033742-Odds Ratio,
pubmed-meshheading:20033742-Polymorphism, Single Nucleotide,
pubmed-meshheading:20033742-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20033742-Young Adult
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| pubmed:year |
2010
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| pubmed:articleTitle |
Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population.
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| pubmed:affiliation |
Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, People's Republic of China. krzhang_sxmu@vip.163.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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