Linked Life Data

20032963

Source:http://linkedlifedata.com/resource/pubmed/id/20032963

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-3-12
pubmed:abstractText
The metabolism of high-fructose corn syrup used to sweeten soda drinks may lead to elevations in uric acid levels. Here we determined whether soda drinking is associated with hyperuricemia and, as a potential consequence, reduced kidney function. At baseline, 15,745 patients in the Atherosclerosis Risk in Communities Study completed a dietary questionnaire and had measurements of their serum creatinine and uric acid. After 3 and 9 years of follow-up, multivariate odds ratios from logistic regressions for binary outcome of hyperuricemia and chronic kidney disease (eGFR less than 60 ml/min per 1.73 m(2)) were evaluated. Compared to participants who drank less, consumption of over one soda per day was associated with increased odds of prevalent hyperuricemia and chronic kidney disease. The odds ratio for chronic kidney disease significantly increased to 2.59 among participants who drank more than one soda per day and had a serum uric acid level over 9.0 mg/dl. In longitudinal analyses, however, drinking more than one soda per day was not associated with hyperuricemia or chronic kidney disease. Neither preexistent hyperuricemia nor development of hyperuricemia modified the lack of association between soda drinking and incident chronic kidney disease. Thus our study shows that high consumption of sugar-sweetened soda was associated with prevalent but not incident hyperuricemia and chronic kidney disease.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/HHSN268200625226C, http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55015, http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55016, http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55018, http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55019, http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55020, http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55021, http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55022, http://linkedlifedata.com/resource/pubmed/grant/R01HL086694, http://linkedlifedata.com/resource/pubmed/grant/R01HL087641, http://linkedlifedata.com/resource/pubmed/grant/R01HL59367, http://linkedlifedata.com/resource/pubmed/grant/U01HG004402, http://linkedlifedata.com/resource/pubmed/grant/UL1RR025005
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1523-1755
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
609-16
pubmed:dateRevised
2010-9-21
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Sugar-sweetened soda consumption, hyperuricemia, and kidney disease.
pubmed:affiliation
Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. asb68@columbia.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural