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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-12-24
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pubmed:abstractText |
The multidrug resistance proteins (MRPs) form a subfamily within the ATP binding cassette transporters that confer resistance to a variety of structurally unrelated compounds. MRP4 has been reported to transport antiretroviral drugs out of cells in an active process. Although the main therapeutic effects of non-steroidal anti-inflammatory drugs (NSAIDs) are their ability to inhibit cyclooxygenase activity, in recent years, some pharmacological effects independent of this action have been described, such as inhibition of the activity of MRP4.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
2040-2058
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1101-11
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pubmed:meshHeading |
pubmed-meshheading:20032540-Anti-HIV Agents,
pubmed-meshheading:20032540-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:20032540-Cell Line,
pubmed-meshheading:20032540-Drug Synergism,
pubmed-meshheading:20032540-HIV-1,
pubmed-meshheading:20032540-Humans,
pubmed-meshheading:20032540-Ibuprofen,
pubmed-meshheading:20032540-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:20032540-Reverse Transcriptase Inhibitors,
pubmed-meshheading:20032540-T-Lymphocytes
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pubmed:year |
2009
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pubmed:articleTitle |
Non-steroidal anti-inflammatory drugs increase the antiretroviral activity of nucleoside reverse transcriptase inhibitors in HIV type-1-infected T-lymphocytes: role of multidrug resistance protein 4.
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pubmed:affiliation |
Laboratory Inmuno-Biología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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