Linked Life Data

20032204

Source:http://linkedlifedata.com/resource/pubmed/id/20032204

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 5
pubmed:dateCreated
2010-4-16
pubmed:abstractText
Pleiotrophin (PTN) is a polypeptide that belongs to a family of heparin-binding growth factors; it displays mitogenic activity for a wide variety of cells. In a previous study, we reported that PTN induces the stimulation of expression of inflammatory cytokines, including tumour necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta and IL-6, in quiescent human peripheral blood mononuclear cells (PBMCs) through B-lymphocyte binding. These results emphasize the importance of PTN in the regulation of inflammatory processes. Moreover, using in vitro infection of PBMCs or using PBMCs from AIDS patients, we showed that PTN was sufficient to induce human immunodeficiency virus type 1 (HIV-1) replication. Moreover, neutralization of TNF-alpha, IL-1beta and IL-6 suppressed HIV replication in PTN-stimulated PBMCs. As these cytokines are potent upregulators of virus expression, these results should prove useful in investigating the role of PTN as a host factor in the regulation of pathological disorders in HIV-1 infection. Identification of this host factor could be important for understanding HIV disease and designating therapeutic approaches.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1465-2099
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1346-53
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Host factor pleiotrophin induces human immunodeficiency virus type 1 replication associated with inflammatory cytokine expression.
pubmed:affiliation
Laboratoire des Interferons/Sarcolectine, Université René Descartes, 45 rue des Saints-Pères, 75006 Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't