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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1991-4-18
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pubmed:abstractText |
In 10 patients with Guillain-Barré syndrome the level of globulins and immunoglobulins before and after plasmapheresis was investigated. As a plasma substitute either PPL (in 8 patients) or a plasma substitute solution rich in immunoglobulins (in 2 patients) was used. When plasma was substituted with PPL, the globulins and immunoglobulins dropped to a mean of 40% of the initial value (range 30-60%) after the first plasmapheresis. With daily or alternate day plasmapheresis, the globulins only partially recovered. Before the second plasmapheresis they were still reduced to a mean of 50% (range 20-50%), and dropped further with ongoing exchanges to a mean of 33% (range 20-50%) as measured before the third plasmapheresis. Accordingly, there was a loss of immunoglobulins of similar magnitude. With the use of a plasma substitute solution rich in immunoglobulins (IRP), globulins could be maintained at normal levels. The lowest immunoglobulin values measured after plasmapheresis were 6 g/l (normal range 8-17 g/l). One patient developed gram-negative septicaemia after plasmapheresis with PPL, possibly due to a low immunoglobulin concentration. We conclude that a plasma substitute solution rich in immunoglobulins should be used for therapeutic plasmapheresis in order to maintain physiological immunoglobulin concentrations.
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pubmed:language |
ger
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-7672
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
2
|
pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2003210-Adult,
pubmed-meshheading:2003210-Aged,
pubmed-meshheading:2003210-Female,
pubmed-meshheading:2003210-Humans,
pubmed-meshheading:2003210-Immunoglobulins,
pubmed-meshheading:2003210-Immunologic Deficiency Syndromes,
pubmed-meshheading:2003210-Male,
pubmed-meshheading:2003210-Middle Aged,
pubmed-meshheading:2003210-Plasma Substitutes,
pubmed-meshheading:2003210-Plasmapheresis,
pubmed-meshheading:2003210-Polyradiculoneuropathy
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pubmed:year |
1991
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pubmed:articleTitle |
[Immunoglobulin deficiency after repeated plasmapheresis].
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pubmed:affiliation |
Departement Innere Medizin, Kantonsspital Basel.
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pubmed:publicationType |
Journal Article,
English Abstract
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