|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2010-5-3
|
|
pubmed:abstractText |
ZM336372 is small molecule tyrosine kinase modulator. It has been shown to inhibit glycogen synthase kinase-3beta (GSK-3beta) through phosphorylation of GSK-3beta at Ser 9. GSK-3beta has previously been shown to mediate cell survival in pancreatic cancer cells. Here we determine the effects of ZM336372 on GSK-3beta phosphorylation, apoptosis, and growth in pancreatic adenocarcinoma cell lines.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1095-8673
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Published by Elsevier Inc.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
161
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
28-32
|
|
pubmed:dateRevised |
2011-11-2
|
|
pubmed:meshHeading |
pubmed-meshheading:20031160-Adenocarcinoma,
pubmed-meshheading:20031160-Apoptosis,
pubmed-meshheading:20031160-Benzamides,
pubmed-meshheading:20031160-Cell Line, Tumor,
pubmed-meshheading:20031160-Cell Proliferation,
pubmed-meshheading:20031160-Drug Evaluation, Preclinical,
pubmed-meshheading:20031160-Glycogen Synthase Kinase 3,
pubmed-meshheading:20031160-Humans,
pubmed-meshheading:20031160-Lithium Chloride,
pubmed-meshheading:20031160-Pancreatic Neoplasms,
pubmed-meshheading:20031160-Phosphorylation,
pubmed-meshheading:20031160-Poly(ADP-ribose) Polymerases
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines.
|
|
pubmed:affiliation |
Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
