Linked Life Data

20028329

Source:http://linkedlifedata.com/resource/pubmed/id/20028329

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-12-23
pubmed:abstractText
Rapid sequence intubation is an essential bullet in the maintenance of patency of the airway during intubation in emergency. It is a valid method in all those situations where you can not determine whether the patient is fasting or not. But RSI is not applicable in all critically ill patients. The presence of severe acidosis, depletion of intravascular volume, heart failure and severe pulmonary disease may complicate the pre-induction period as the induction, leading to the onset of vasodilatation and hypotension. Another complication is represented by Hypoxemia during the manoeuvre. The algorithm of RSI consists in six steps: pre-oxygenation, premedication, myo-relaxation and induction, intubation, primary and secondary confirmation, post-intubation patient management. Propofol has replaced Thiopental as the most common intravenous ipnotic. In hypotensive patients Ketamine represents a viable alternative. Succinylcholine is the most common neuromuscular relaxant used in the RSI. The not depolarizing NMBAs are an alternative to Succinylcholine. Among these, the most important is the Rocuronium. This drug is characterized by a fairly rapid onset (1-2 min) and an intermediate half-life (45-70 min). The onset depends on the dosage used. The problem that limits the use of Rocuronium is the fact that its duration of action is much longer than that of Succinylcholine, especially when used at higher doses. This problem can be solved through the use of Sugammadex. As a muscle relaxant chelating Sugammadex antagonizes the effects induced by Rocuronium on muscle tissue and quickly resolve the blockade.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Androstanols, http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Dissociative, http://linkedlifedata.com/resource/pubmed/chemical/Hypnotics and Sedatives, http://linkedlifedata.com/resource/pubmed/chemical/Ketamine, http://linkedlifedata.com/resource/pubmed/chemical/Neuromuscular Depolarizing Agents, http://linkedlifedata.com/resource/pubmed/chemical/Neuromuscular Nondepolarizing Agents, http://linkedlifedata.com/resource/pubmed/chemical/Propofol, http://linkedlifedata.com/resource/pubmed/chemical/Succinylcholine, http://linkedlifedata.com/resource/pubmed/chemical/Sugammadex, http://linkedlifedata.com/resource/pubmed/chemical/Thiopental, http://linkedlifedata.com/resource/pubmed/chemical/gamma-Cyclodextrins, http://linkedlifedata.com/resource/pubmed/chemical/rocuronium
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1876-1038
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Rapid sequence intubation: a review of recent evidences.
pubmed:affiliation
Department of Critical Care Medicine and Surgery, University of Florence, Careggi Teaching Hospital; Viale Morgagni 85, 50139, Florence, Italy. adifilippo@unifi.it
pubmed:publicationType
Journal Article, Review