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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-12-22
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pubmed:abstractText |
The type-1 cytokine pathway plays a pivotal role in immunity against intracellular bacterial pathogens such as Salmonellae and Mycobacteria. Bacterial stimulation of pattern recognition receptors on monocytes, macrophages and dendritic cells initiates this pathway, and results in the production of cytokines that activate lymphocytes to produce interferon (IFN)-gamma. Interleukin (IL)-12 and IL-23 are thought to be the key cytokines required for initiating a type-1 cytokine immune response to Mycobacteria and Salmonellae. The relative contribution of IL-23 and IL-12 to this process is uncertain.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-10201989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-10653850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-10993913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-11114383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-11241284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-11905407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-12421946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-15070757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-15143479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-15384045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-15995707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-16157683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-16330536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-16513390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-16867152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-17359235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-17372002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-17919942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-18319062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-18319400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-18490488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-18927625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-19088061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-2465038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-3258884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-7605994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-7836910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-7923877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-8097322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-8551218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-8924355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-9394800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-9548515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20027291-9616161
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD56,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-23,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e8396
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:20027291-Antigens, CD56,
pubmed-meshheading:20027291-Cells, Cultured,
pubmed-meshheading:20027291-Cytokines,
pubmed-meshheading:20027291-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:20027291-Humans,
pubmed-meshheading:20027291-Interferon-gamma,
pubmed-meshheading:20027291-Interleukin-12,
pubmed-meshheading:20027291-Interleukin-18,
pubmed-meshheading:20027291-Interleukin-1beta,
pubmed-meshheading:20027291-Interleukin-23,
pubmed-meshheading:20027291-Lipopolysaccharides,
pubmed-meshheading:20027291-Macrophages,
pubmed-meshheading:20027291-Microbial Viability,
pubmed-meshheading:20027291-Monocytes,
pubmed-meshheading:20027291-Natural Killer T-Cells,
pubmed-meshheading:20027291-Salmonella,
pubmed-meshheading:20027291-Salmonella Infections,
pubmed-meshheading:20027291-Subcellular Fractions,
pubmed-meshheading:20027291-Toll-Like Receptors
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pubmed:year |
2009
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pubmed:articleTitle |
Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells.
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pubmed:affiliation |
Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article
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