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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-4-17
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pubmed:abstractText |
The cocaine binding site at the dopamine transporter has been found to be stereoselective. Thus, the seven possible stereoisomers of (-)-cocaine have been synthesized and found to inhibit [3H]-2 beta-carbomethoxy-3 beta-(4-fluoro-phenyl)tropane [( 3H]WIN 35,428) with potencies ranging from 1/60 to 1/600 of that of (-)-cocaine. The synthesis and characterization of all new compounds is presented.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
883-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2002468-Animals,
pubmed-meshheading:2002468-Binding, Competitive,
pubmed-meshheading:2002468-Carrier Proteins,
pubmed-meshheading:2002468-Cell Membrane,
pubmed-meshheading:2002468-Chemical Phenomena,
pubmed-meshheading:2002468-Chemistry,
pubmed-meshheading:2002468-Cocaine,
pubmed-meshheading:2002468-Corpus Striatum,
pubmed-meshheading:2002468-Male,
pubmed-meshheading:2002468-Molecular Structure,
pubmed-meshheading:2002468-Rats,
pubmed-meshheading:2002468-Rats, Inbred Strains,
pubmed-meshheading:2002468-Receptors, Drug,
pubmed-meshheading:2002468-Stereoisomerism
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pubmed:year |
1991
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pubmed:articleTitle |
Synthesis and ligand binding of cocaine isomers at the cocaine receptor.
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pubmed:affiliation |
Chemistry and Life Sciences, Research Triangle Institute, North Carolina 27709.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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