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rdf:type |
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lifeskim:mentions |
umls-concept:C0013336,
umls-concept:C0023884,
umls-concept:C0026809,
umls-concept:C0205164,
umls-concept:C0242692,
umls-concept:C0870432,
umls-concept:C1418947,
umls-concept:C1555465,
umls-concept:C1704259,
umls-concept:C1705417,
umls-concept:C1705987,
umls-concept:C1881189,
umls-concept:C2346484
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pubmed:issue |
2
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pubmed:dateCreated |
2010-3-24
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pubmed:abstractText |
Growth hormone (GH) is an anabolic hormone that regulates growth and metabolism. Ames dwarf mice are natural mutants for Prop1, with impaired development of anterior pituitary and undetectable levels of circulating GH, prolactin and TSH. They constitute an endocrine model of life-long GH-deficiency. The main signaling cascades activated by GH binding to its receptor are the JAK2/STATs, PI-3K/Akt and the MAPK Erk1/2 pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Prophet of Pit-1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Somatotropin,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/mTOR protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1532-2238
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
118-26
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20022531-Animals,
pubmed-meshheading:20022531-Drug Resistance,
pubmed-meshheading:20022531-Dwarfism, Pituitary,
pubmed-meshheading:20022531-Glycogen Synthase Kinase 3,
pubmed-meshheading:20022531-Growth Hormone,
pubmed-meshheading:20022531-Homeodomain Proteins,
pubmed-meshheading:20022531-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:20022531-Liver,
pubmed-meshheading:20022531-Mice,
pubmed-meshheading:20022531-Mice, Transgenic,
pubmed-meshheading:20022531-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:20022531-Muscle, Skeletal,
pubmed-meshheading:20022531-Phosphorylation,
pubmed-meshheading:20022531-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20022531-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20022531-Receptors, Somatotropin,
pubmed-meshheading:20022531-STAT3 Transcription Factor,
pubmed-meshheading:20022531-STAT5 Transcription Factor,
pubmed-meshheading:20022531-Signal Transduction,
pubmed-meshheading:20022531-TOR Serine-Threonine Kinases
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pubmed:year |
2010
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pubmed:articleTitle |
Ames dwarf (Prop1(df)/Prop1(df)) mice display increased sensitivity of the major GH-signaling pathways in liver and skeletal muscle.
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pubmed:affiliation |
Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Caba, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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