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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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|
pubmed:dateCreated |
2010-2-3
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|
pubmed:abstractText |
Bis-oximinoalkanoic acid derivatives were designed and synthesized to aid in the characterization of selective PPARalpha agonists by replacing the oxazole ring with flexible oximino group in the lipophilic tail part of a previously reported compound 3. Selected compounds 9d and 9m showed excellent potency and high selectivity towards PPARalpha in vitro. These compounds found effective in reducing serum triglycerides (TG) in vivo.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1464-3405
|
|
pubmed:author |
pubmed-author:GiriSureshS,
pubmed-author:JainMukulM,
pubmed-author:MakadiaPankajP,
pubmed-author:PatelDarshitD,
pubmed-author:PatelPankajP,
pubmed-author:PatilPravinP,
pubmed-author:PingaliHarikishoreH,
pubmed-author:PolaSureshS,
pubmed-author:PriyadarshiniPriyankaP,
pubmed-author:ShahMaananM,
pubmed-author:ShahShaileshS,
pubmed-author:SutharDineshD,
pubmed-author:ThubeBabanB,
pubmed-author:ZawarePandurangP
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pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1156-61
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|
pubmed:dateRevised |
2010-11-18
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|
pubmed:meshHeading |
|
|
pubmed:year |
2010
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|
pubmed:articleTitle |
Design and synthesis of novel bis-oximinoalkanoic acids as potent PPAR alpha agonists.
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|
pubmed:affiliation |
Zydus Research Centre, Sarkhej-Bavla NH 8A Moraiya, Ahmedabad 382 210, India. pingalihk@rediffmail.com
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pubmed:publicationType |
Journal Article,
Comparative Study
|
