|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2010-2-9
|
|
pubmed:abstractText |
NR2B-subtype-selective antagonists differ from MK-801, a nonselective NMDA receptor antagonist. MK-801 antagonizes electrical seizures at doses as low as 0.1 to 0.18mg/kg and elicits popping at doses as low as 0.5mg/kg, whereas ifenprodil and Ro 8-4304 were unable to do so at the doses tested. Ro 25-6981, however, was able to antagonize electrically-precipitated tonic hindlimb extension at 100mg/kg, but was not able to elicit popping behavior at this dose.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1873-7862
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2009 Elsevier B.V. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
207-10
|
|
pubmed:meshHeading |
pubmed-meshheading:20022475-Animals,
pubmed-meshheading:20022475-Dose-Response Relationship, Drug,
pubmed-meshheading:20022475-Electroshock,
pubmed-meshheading:20022475-Male,
pubmed-meshheading:20022475-Mice,
pubmed-meshheading:20022475-Phenols,
pubmed-meshheading:20022475-Piperidines,
pubmed-meshheading:20022475-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:20022475-Seizures
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
NMDA NR2B subtype-selective receptor antagonists fail to antagonize electrically-precipitated seizures and elicit popping in mice.
|
|
pubmed:affiliation |
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 710, Norfolk, Virginia 23507-1912, United States.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.
|
