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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-9
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pubmed:abstractText |
The introduction of drug-eluting stents (DES) has largely added benefit to the percutaneous coronary intervention. Questions about the long-term safety of DES have been raised, however, particularly with respect to late stent thrombosis. Research efforts are now being directed toward therapeutics that can impede smooth muscle proliferation and promote vascular healing. Emerging data suggest that heme oxygenase-1 (HO-1), an inducible oxidoreductase enzyme system, can exert cytoprotective effects on endothelial cells and limit smooth muscle cell proliferation. We assessed the ability of hemin, a potent HO-1 inducer, to reduce in-stent stenosis without compromising re-endothelialization.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Monoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase (Decyclizing),
http://linkedlifedata.com/resource/pubmed/chemical/Hemin,
http://linkedlifedata.com/resource/pubmed/chemical/Hmox1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Metalloporphyrins,
http://linkedlifedata.com/resource/pubmed/chemical/Metals,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Organometallic Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Protoporphyrins,
http://linkedlifedata.com/resource/pubmed/chemical/rhoA GTP-Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/tin protoporphyrin IX,
http://linkedlifedata.com/resource/pubmed/chemical/tricarbonylchloro(glycinato)rutheniu...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1097-6809
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
417-28
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pubmed:meshHeading |
pubmed-meshheading:20022212-Angioplasty,
pubmed-meshheading:20022212-Animals,
pubmed-meshheading:20022212-Apoptosis,
pubmed-meshheading:20022212-Arterial Occlusive Diseases,
pubmed-meshheading:20022212-Carbon Monoxide,
pubmed-meshheading:20022212-Cell Proliferation,
pubmed-meshheading:20022212-Constriction, Pathologic,
pubmed-meshheading:20022212-Cyclin-Dependent Kinase Inhibitor Proteins,
pubmed-meshheading:20022212-Disease Models, Animal,
pubmed-meshheading:20022212-Drug-Eluting Stents,
pubmed-meshheading:20022212-Endothelium, Vascular,
pubmed-meshheading:20022212-Enzyme Induction,
pubmed-meshheading:20022212-Enzyme Inhibitors,
pubmed-meshheading:20022212-Heme Oxygenase (Decyclizing),
pubmed-meshheading:20022212-Hemin,
pubmed-meshheading:20022212-Hypercholesterolemia,
pubmed-meshheading:20022212-Iliac Artery,
pubmed-meshheading:20022212-Injections, Intraperitoneal,
pubmed-meshheading:20022212-Ki-67 Antigen,
pubmed-meshheading:20022212-Male,
pubmed-meshheading:20022212-Metalloporphyrins,
pubmed-meshheading:20022212-Metals,
pubmed-meshheading:20022212-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:20022212-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:20022212-Muscle, Smooth, Vascular,
pubmed-meshheading:20022212-Organometallic Compounds,
pubmed-meshheading:20022212-Prosthesis Design,
pubmed-meshheading:20022212-Protoporphyrins,
pubmed-meshheading:20022212-Rabbits,
pubmed-meshheading:20022212-Rats,
pubmed-meshheading:20022212-Rats, Wistar,
pubmed-meshheading:20022212-Stents,
pubmed-meshheading:20022212-Time Factors,
pubmed-meshheading:20022212-rhoA GTP-Binding Protein
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pubmed:year |
2010
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pubmed:articleTitle |
Hemin prevents in-stent stenosis in rat and rabbit models by inducing heme-oxygenase-1.
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pubmed:affiliation |
Laboratoire de Physiopathologie de la Paroi Artérielle, EA3852, IFR135, Faculté de Médecine, Université François Rabelais Tours, France. hyvelin.jean-marc@neuf.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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