Source:http://linkedlifedata.com/resource/pubmed/id/20022107
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2010-1-29
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| pubmed:abstractText |
For an improved hemocompatibility of 316L stainless steel (SS), we develop a facile and effective approach to fabricating a pulsed-plasma polymeric allylamine (P-PPAm) film that possesses a high cross-linking degree and a high density of amine groups, which is used for subsequent bonding of heparin. The P-PPAm film as a stent coating shows good resistance to the deformation behavior of compression and expansion of a stent. Using deionized water as an aging medium, it is demonstrated that the heparin-immobilized P-PPAm (Hep-P-PPAm) surface has a good retention of heparin. The systematic in vitro hemocompatibility evaluation reveals lower platelet adhesion, platelet activation and fibrinogen activation on the Hep-P-PPAm surface, and the activated partial thromboplastin time prolongs for about 15 s compared with 316L SS. The P-PPAm surface significantly promotes adhesion and proliferation of endothelial cells (ECs). For the Hep-P-PPAm, although EC adhesion and proliferation is slightly suppressed initially, after cultivation for 3 days, the growth behavior of ECs is remarkably improved over 316L SS. In vivo results indicate that the Hep-P-PPAm surface successfully restrain thrombus formation by growing a homogeneous and intact shuttle-like endothelium on its surface. The Hep-P-PPAm modified 316L SS shows a promising application for vascular devices.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Allylamine,
http://linkedlifedata.com/resource/pubmed/chemical/Coated Materials, Biocompatible,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrinogen,
http://linkedlifedata.com/resource/pubmed/chemical/Heparin,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/Stainless Steel
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1878-5905
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2072-83
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| pubmed:meshHeading |
pubmed-meshheading:20022107-Allylamine,
pubmed-meshheading:20022107-Cell Adhesion,
pubmed-meshheading:20022107-Cell Proliferation,
pubmed-meshheading:20022107-Cells, Cultured,
pubmed-meshheading:20022107-Coated Materials, Biocompatible,
pubmed-meshheading:20022107-Electrochemical Techniques,
pubmed-meshheading:20022107-Endothelial Cells,
pubmed-meshheading:20022107-Fibrinogen,
pubmed-meshheading:20022107-Hemolysis,
pubmed-meshheading:20022107-Heparin,
pubmed-meshheading:20022107-Humans,
pubmed-meshheading:20022107-Materials Testing,
pubmed-meshheading:20022107-Platelet Activation,
pubmed-meshheading:20022107-Platelet Adhesiveness,
pubmed-meshheading:20022107-Polymers,
pubmed-meshheading:20022107-Spectroscopy, Fourier Transform Infrared,
pubmed-meshheading:20022107-Stainless Steel,
pubmed-meshheading:20022107-Stents,
pubmed-meshheading:20022107-Surface Properties
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| pubmed:year |
2010
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| pubmed:articleTitle |
The covalent immobilization of heparin to pulsed-plasma polymeric allylamine films on 316L stainless steel and the resulting effects on hemocompatibility.
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| pubmed:affiliation |
Key Laboratory of Advanced Technology for Materials of Education Ministry, Southwest Jiaotong University, Chengdu 610031, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
|