Linked Life Data

20022095

Source:http://linkedlifedata.com/resource/pubmed/id/20022095

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-2-17
pubmed:abstractText
Respiratory stimulants are widely used in asphyxic neonatal calves despite a lack of data about their effectiveness and indications of possible side effects. The effect of doxapram and theophylline on respiratory, cardiovascular, and acid-base variables was investigated in 10 healthy neonatal calves (Bos Taurus). A venous, a peripheral arterial, and a pulmonary arterial catheter were placed, and central venous, pulmonary, and systemic blood pressures and cardiac output were measured using thermodilution technique. Doxapram, but not theophylline, led to an immediate increase in respiratory rate (P <or= 0.01). The arterial pCO(2) decreased to 27.1+/-4.7 mm Hg within 30 sec after doxapram administration and to 46.3+/-5.8 mm Hg within 120 min after theophylline administration (P<0.0001). The systolic pulmonary pressure increased from 70+/-8mm Hg (mean+/-SD) to 93+/-19 mm Hg within 30 sec after doxapram, but decreased after theophylline. The pulmonary vascular resistance also increased after doxapram and decreased after theophylline (P<0.01). Doxapram had a more pronounced and faster effect on respiratory rate and elimination of CO(2) than theophylline. Doxapram, but not theophylline, is indicated for treatment of postnatal asphyxia in calves, but there are potential cardiovascular side effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1879-3231
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
612-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Respiratory and cardiovascular effects of doxapram and theophylline for the treatment of asphyxia in neonatal calves.
pubmed:affiliation
Clinic of Reproductive Medicine, Department of Food Animals, Vetsuisse-Faculty University of Zurich, Zurich, Switzerland. ubleul@vetclinics.uzh.ch
pubmed:publicationType
Journal Article, Randomized Controlled Trial