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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-8-2
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pubmed:abstractText |
Convection-enhanced delivery (CED) is a novel intracerebral drug delivery technique with considerable promise for delivering therapeutic agents throughout the CNS. Despite this promise, Phase III clinical trials employing CED have failed to meet clinical end points. Although this may be due to inactive agents or a failure to rigorously validate drug targets, the authors have previously demonstrated that catheter positioning plays a major role in drug distribution using this technique. The purpose of the present work was to retrospectively analyze the expected drug distribution based on catheter positioning data available from the CED arm of the PRECISE trial.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1933-0693
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pubmed:author |
pubmed-author:ArcherGaryG,
pubmed-author:BradyMartin LML,
pubmed-author:ChangSusan MSM,
pubmed-author:CoanAprilA,
pubmed-author:CroteauDavidD,
pubmed-author:FriedmanAllan HAH,
pubmed-author:FriedmanHenry SHS,
pubmed-author:HerndonJames EJE,
pubmed-author:KunwarSandeepS,
pubmed-author:MittermeyerStephanS,
pubmed-author:PRECISE Trial Investigators,
pubmed-author:PedainChristophC,
pubmed-author:PuriRaj KRK,
pubmed-author:RaghavanRaghuR,
pubmed-author:ReardonDavid ADA,
pubmed-author:Rodríguez-PonceM InmaculadaMI,
pubmed-author:SampsonJohn HJH,
pubmed-author:VogelbaumMichael AMA,
pubmed-author:Wembacher-SchröderEvaE,
pubmed-author:WestphalManfredM
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pubmed:issnType |
Electronic
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20020841-Algorithms,
pubmed-meshheading:20020841-Antineoplastic Agents,
pubmed-meshheading:20020841-Brain Neoplasms,
pubmed-meshheading:20020841-Catheterization,
pubmed-meshheading:20020841-Clinical Trials, Phase III as Topic,
pubmed-meshheading:20020841-Convection,
pubmed-meshheading:20020841-Drug Delivery Systems,
pubmed-meshheading:20020841-Humans,
pubmed-meshheading:20020841-Interleukin-13,
pubmed-meshheading:20020841-Kaplan-Meier Estimate,
pubmed-meshheading:20020841-Proportional Hazards Models,
pubmed-meshheading:20020841-Randomized Controlled Trials as Topic,
pubmed-meshheading:20020841-Retrospective Studies,
pubmed-meshheading:20020841-Software,
pubmed-meshheading:20020841-Tissue Distribution,
pubmed-meshheading:20020841-Treatment Failure
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pubmed:year |
2010
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pubmed:articleTitle |
Poor drug distribution as a possible explanation for the results of the PRECISE trial.
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pubmed:affiliation |
Division of Neurosurgery, Department of Surgery, Duke University, Durham, North Carolina, USA. john.sampson@duke.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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