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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-1-21
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pubmed:abstractText |
Molecular pathogenesis of gastrointestinal polyposis in Peutz-Jegher's syndrome (PJS) has been linked to the loss-of-function mutation of LKB1. Recent functional genetic studies have pointed out that LKB1 plays a physiological role in controlling the Wnt-signaling pathway and activation of the pathway as a consequence of LKB1 haploinsufficiency might be responsible for the development of harmatomatous polyps. This study aimed to look for immunohistochemical evidence of Wnt-signaling activation in PJS polyps.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1437-9813
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-7
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pubmed:meshHeading |
pubmed-meshheading:20020146-Adolescent,
pubmed-meshheading:20020146-Child,
pubmed-meshheading:20020146-Child, Preschool,
pubmed-meshheading:20020146-DNA, Neoplasm,
pubmed-meshheading:20020146-Female,
pubmed-meshheading:20020146-Genotype,
pubmed-meshheading:20020146-Germ-Line Mutation,
pubmed-meshheading:20020146-Humans,
pubmed-meshheading:20020146-Immunohistochemistry,
pubmed-meshheading:20020146-Infant,
pubmed-meshheading:20020146-Male,
pubmed-meshheading:20020146-Peutz-Jeghers Syndrome,
pubmed-meshheading:20020146-Polymerase Chain Reaction,
pubmed-meshheading:20020146-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20020146-Retrospective Studies,
pubmed-meshheading:20020146-Young Adult,
pubmed-meshheading:20020146-beta Catenin
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pubmed:year |
2010
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pubmed:articleTitle |
Immunohistological evidence for Wnt-signaling activation in Peutz-Jeghers polyposis.
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pubmed:affiliation |
Tumor Biology Research Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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