Source:http://linkedlifedata.com/resource/pubmed/id/20019681
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2010-7-28
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| pubmed:abstractText |
This study tests the hypothesis that a high-fat postnatal diet increases fat mass and reduces improved insulin sensitivity (IS) found in the low-protein model of maternal undernutrition. Offspring from Wistar dams fed either a 20% (control (CON)) or 8% (low protein (LP)) protein diet during gestation and lactation were randomly assigned to a control (con) or cafeteria (caf) diet at weaning (21 days) until 3 months of age at which point IS was measured (hyperinsulinemic-euglycemic clamp). Fat mass, growth, energy intake (EI) and expenditure (EE), fuel utilization, insulin secretion, and leptin and adiponectin levels were measured to identify a possible role in any changes in IS. IS was increased in LP-con in comparison to CON-con animals. Cafeteria feeding prevented this increase in LP animals but had no effect in CON animals (insulin-stimulated glucose infusion rates (GIRs; mg/min/kg); CON-con: 13.9 +/- 1.0, CON caf: 12.1 +/- 2.1, LP-con: 25.4 +/- 2.0, LP-caf: 13.7 +/- 3.7, P < 0.05). CON-caf animals had similar percent epididymal white adipose tissue (%EWAT; CON-con: 1.71 +/- 0.09 vs. CON-caf: 1.66 +/- 0.08) and adiponectin (microg/ml: CON-con: 4.61 +/- 0.34 vs. CON-caf: 3.67 +/- 0.18) except hyperinsulinemia and relative hyperleptinemia in comparison to CON-con. Differently, LP-caf animals had increased %EWAT (LP-con: 1.11 +/- 0.06 vs. LP-caf: 1.44 +/- 0.08, P < 0.05) and adiponectin (microg/ml: LP-con: 5.38 +/- 0.39 vs. LP-caf: 3.75 +/- 0.35, P < 0.05) but did not show cafeteria-induced hyperinsulinemia or relative hyperleptinemia. An increased propensity to store visceral fat in LP animals may prevent the elevated IS in LP offspring.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
1930-7381
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1593-600
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:20019681-Adiponectin,
pubmed-meshheading:20019681-Animals,
pubmed-meshheading:20019681-Animals, Newborn,
pubmed-meshheading:20019681-Blood Glucose,
pubmed-meshheading:20019681-Diet, Protein-Restricted,
pubmed-meshheading:20019681-Dietary Fats,
pubmed-meshheading:20019681-Female,
pubmed-meshheading:20019681-Hyperinsulinism,
pubmed-meshheading:20019681-Insulin,
pubmed-meshheading:20019681-Insulin Resistance,
pubmed-meshheading:20019681-Intra-Abdominal Fat,
pubmed-meshheading:20019681-Leptin,
pubmed-meshheading:20019681-Male,
pubmed-meshheading:20019681-Obesity, Abdominal,
pubmed-meshheading:20019681-Pregnancy,
pubmed-meshheading:20019681-Random Allocation,
pubmed-meshheading:20019681-Rats,
pubmed-meshheading:20019681-Rats, Wistar
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| pubmed:year |
2010
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| pubmed:articleTitle |
Elevated insulin sensitivity in low-protein offspring rats is prevented by a high-fat diet and is associated with visceral fat.
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| pubmed:affiliation |
Human Nutrition Unit, The University of Sydney, Sydney, New South Wales, Australia. alison.gosby@usyd.edu.au
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|