Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-3-1
pubmed:abstractText
Wnts are secreted, lipidated proteins that regulate multiple aspects of brain development, including dopaminergic neuron development. In this study, we perform the first purification and signaling analysis of Wnt2 and define the function of Wnt2 in ventral midbrain precursor cultures, as well as in Wnt2-null mice in vivo. We found that purified Wnt2 induces the phosphorylation of both Lrp5/6 and Dvl-2/3, and activates beta-catenin in SN4741 dopaminergic cells. Moreover, purified Wnt2 increases progenitor proliferation, and the number of dopaminergic neurons in ventral midbrain precursor cultures. In agreement with these findings, analysis of the ventral midbrain of developing Wnt2-null mice revealed a decrease in progenitor proliferation and neurogenesis that lead to a decrease in the number of postmitotic precursors and dopaminergic neurons. Collectively, our observations identify Wnt2 as a novel regulator of dopaminergic progenitors and dopaminergic neuron development.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-11092808, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-11779461, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-11959819, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-12105418, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-12130776, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-12138115, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-12717451, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-12791979, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-14557550, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-14625142, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-15121182, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-15229603, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-15522889, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-15686623, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-15748172, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-16339193, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-16510140, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-16602827, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-16772171, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-17013885, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-17244647, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-18060047, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-18832390, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-18953410, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-19000841, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-19056682, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-19122665, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-19497282, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-19619488, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-19686689, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-2202907, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-2205396, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-2883581, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-2971536, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-7512949, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-8951051, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-9006067, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-9389482, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-9419423, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-9624183, http://linkedlifedata.com/resource/pubmed/commentcorrection/20018874-9870933
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1083-351X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
285
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7246-53
pubmed:dateRevised
2011-7-26
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Wnt2 regulates progenitor proliferation in the developing ventral midbrain.
pubmed:affiliation
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles väg 1, A1:2, 17177 Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't