Linked Life Data

20018456

Source:http://linkedlifedata.com/resource/pubmed/id/20018456

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-4-7
pubmed:abstractText
Distraction osteogenesis, currently a standard method of bone lengthening, is based upon the "tension-stress principle", as proposed by G.A. Ilizarov. Mechanical stimulation by distraction induces biological responses of skeletal regeneration that is accomplished by a cascade of biologic processes including differentiation of pluripotential tissue, angiogenesis, mineralization, and remodeling. The exact mechanism by which strain stimulates bone formation remains unclear. Distraction rate and rhythm must have great influence on the quality of the newly formed bone generated by mechanical traction. The preliminary results demonstrated that for a given rate higher frequency of distraction improved the bone formation, but the mechanism remains unclear. In this article we present a hypothesis that the reason why higher frequency of distraction improved the bone formation for a given rate is that higher frequency of distraction provides smaller microtrauma to tissues within the gap and longer existence time of the microenvironment stimulating tissues within the gap than low frequency distraction. This hypothesis, if proven to be valid, will not only represent a breakthrough in research of mechanism of distraction osteogenesis, but also will open a new door to the bone regeneration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1532-2777
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
871-3
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Why high frequency of distraction improved the bone formation in distraction osteogenesis?
pubmed:affiliation
State Key Laboratory of Oral Disease, Sichuan University, Chengdu, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't