Linked Life Data

20018017

Source:http://linkedlifedata.com/resource/pubmed/id/20018017

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-12-18
pubmed:abstractText
ABSTRACT : We compared family-based single-marker association analysis using Merlin and multi-marker analysis using LASSO (least absolute shrinkage and selection operator) for the low-density lipoprotein phenotype at the first visit for all 200 replicates of the Genetic Analysis Workshop 16 Framingham simulated data sets. Using "answers," we selected single-nucleotide polymorphisms (SNPs) on chromosome 22 for comparison of results between single-marker and multi-marker analyses. For the major causal SNP rs2294207 on chromosome 22, both single-marker and multi-marker analyses provided similar results, indicating the importance of this SNP. For the 12 polygenic SNPs on the same chromosome, both single-marker and multi-marker analyses failed to provide statistically significant associations, indicating that their effects were too weak to be detected by either method. The main difference between the two methods was that for the 14 SNPs near the causal SNPs, p-values from Merlin were the next smallest, whereas LASSO often excluded these non-causal neighboring SNPs entirely from the first 10,000 models.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:issn
1753-6561
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3 Suppl 7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S27
pubmed:year
2009
pubmed:articleTitle
Comparison between single-marker analysis using Merlin and multi-marker analysis using LASSO for Framingham simulated data.
pubmed:affiliation
Division of Biostatistics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8067, St, Louis, Missouri 63110-1093, USA. yunju@wubios.wustl.edu.
pubmed:publicationType
Journal Article