Source:http://linkedlifedata.com/resource/pubmed/id/20018004
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2009-12-18
|
| pubmed:abstractText |
ABSTRACT : We conducted a search for non-chromosome 6 genes that may increase risk for rheumatoid arthritis (RA). Our approach was to retrospectively ascertain three "extreme" subsamples from the North American Rheumatoid Arthritis Consortium. The three subsamples are: 1) RA cases who have two low-risk HLA-DRB1 alleles (N = 18), 2) RA cases who have two high-risk HLA-DRB1 alleles (N = 163), and 3) controls who have two low-risk HLA-DRB1 alleles (N = 652). We hypothesized that since Group 1's RA was likely due to non-HLA related risk factors, and because Group 3, by definition, is unaffected, comparing Group 1 with Group 2 and Group 1 with Group 3 would result in the identification of candidate susceptibility loci located outside of the MHC region. Accordingly, we restricted our search to the 21 non-chromosome 6 autosomes. The case-case comparison of Groups 1 and 2 resulted in the identification of 17 SNPs with allele frequencies that differed at p < 0.0001. The case-control comparison of Groups 1 and 3 identified 23 SNPs that differed in allele frequency at p < 0.0001. Eight of these SNPs (rs10498105, rs2398966, rs7664880, rs7447161, rs2793471, rs2611279, rs7967594, and rs742605) were common to both lists.
|
| pubmed:grant | |
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20018004-1139259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20018004-12833157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20018004-14608356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20018004-14749714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20018004-1496989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20018004-15208781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20018004-15821736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20018004-16862161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20018004-17804842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20018004-2446635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20018004-8977961
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:issn |
1753-6561
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
3 Suppl 7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S15
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
A search for non-chromosome 6 susceptibility loci contributing to rheumatoid arthritis.
|
| pubmed:affiliation |
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Campus Box 8134, St, Louis, Missouri 63110, USA. bks@themfs.wustl.edu.
|
| pubmed:publicationType |
Journal Article
|