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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0032659,
umls-concept:C0085228,
umls-concept:C0205245,
umls-concept:C0525045,
umls-concept:C0669368,
umls-concept:C0871261,
umls-concept:C0907533,
umls-concept:C1269683,
umls-concept:C1417759,
umls-concept:C1556094,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1882417,
umls-concept:C2350277,
umls-concept:C2911692
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-5
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pubmed:abstractText |
Nitric oxide has been reported to play a role in neural transmitter release and N-methyl-D-aspartate receptor activation, as well as to be related to oxidative stress. Abnormalities in both of these mechanisms are thought to be involved in the pathophysiology of mood disorders including major depressive disorder (MDD) and bipolar disorder (BP). In addition, several lines of evidence support an association between abnormalities in neuronal nitric oxide synthases (nNOS) and mood disorders. Therefore, we studied the association of nNOS gene (NOS1) and mood disorders and the efficacy of fluvoxamine treatment in Japanese MDD patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0224
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pubmed:author |
pubmed-author:IkedaMasashiM,
pubmed-author:InadaToshiyaT,
pubmed-author:IwataNakaoN,
pubmed-author:KawashimaKunihiroK,
pubmed-author:KinoshitaYokoY,
pubmed-author:KishiTaroT,
pubmed-author:KitajimaTsuyoshiT,
pubmed-author:OkochiTomoT,
pubmed-author:OkumuraTakenoriT,
pubmed-author:OzakiNorioN,
pubmed-author:TsunokaTomokoT,
pubmed-author:YamanouchiYoshioY
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pubmed:issnType |
Electronic
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-63
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pubmed:meshHeading |
pubmed-meshheading:20016223-Adult,
pubmed-meshheading:20016223-Aged,
pubmed-meshheading:20016223-Antidepressive Agents, Second-Generation,
pubmed-meshheading:20016223-Chi-Square Distribution,
pubmed-meshheading:20016223-Depressive Disorder, Major,
pubmed-meshheading:20016223-Female,
pubmed-meshheading:20016223-Fluvoxamine,
pubmed-meshheading:20016223-Gene Frequency,
pubmed-meshheading:20016223-Genome-Wide Association Study,
pubmed-meshheading:20016223-Genotype,
pubmed-meshheading:20016223-Humans,
pubmed-meshheading:20016223-Japan,
pubmed-meshheading:20016223-Male,
pubmed-meshheading:20016223-Middle Aged,
pubmed-meshheading:20016223-Nitric Oxide Synthase Type I,
pubmed-meshheading:20016223-Pharmacogenetics,
pubmed-meshheading:20016223-Polymorphism, Single Nucleotide
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pubmed:year |
2010
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pubmed:articleTitle |
Genetic association analysis of functional polymorphisms in neuronal nitric oxide synthase 1 gene (NOS1) and mood disorders and fluvoxamine response in major depressive disorder in the Japanese population.
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pubmed:affiliation |
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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