Linked Life Data

20016103

Source:http://linkedlifedata.com/resource/pubmed/id/20016103

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
50
pubmed:dateCreated
2009-12-17
pubmed:abstractText
Inhibition of inappropriate responses is an essential executive function needed for adaptation to changing environments. In stop-signal tasks, which are often used to investigate response inhibition, subjects make "go" responses while they prepare to stop at a suddenly given "stop" signal. However, the preparatory processes ongoing before response inhibition have rarely been investigated, and it remains unclear how the preparation contributes to response inhibition. In the present study, a stop-signal task was designed so that the extent of the preparation could be estimated using behavioral and neuroimaging measures. Specifically, in addition to the conventional go trials where preparation to stop was required ("uncertain-go" trials), another type of go trial was introduced where a stop-signal was never given and such preparation was unnecessary ("certain-go" trials). An index reflecting the "preparation cost" was then calculated by subtracting the reaction times in the certain-go trials from those in the uncertain-go trials. It was revealed that the stop signal reaction time, a common index used to evaluate the efficiency of response inhibition, decreased as the preparation cost increased, indicating greater preparation supports more efficient inhibition. In addition, imaging data showed that response inhibition recruited frontoparietal regions (the contrast "stop vs uncertain-go") and that preparation recruited most of the inhibition-related frontoparietal regions (the contrast "uncertain-go vs certain-go"). It was also revealed that the inhibition-related activity declined as the preparation cost increased. These behavioral and imaging results suggest preparation makes a complementary contribution to response inhibition during performance of a stop-signal task.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15870-7
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Preparation to inhibit a response complements response inhibition during performance of a stop-signal task.
pubmed:affiliation
Department of Physiology, The University of Tokyo School of Medicine, Bunkyo-ku, Tokyo 113-0033, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't