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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 5
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pubmed:dateCreated |
2010-4-16
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pubmed:abstractText |
Recent large-scale sequence analyses revealed 'signature' amino acids at specific positions in viral proteins that distinguish human influenza viruses from avian viruses. To determine the role of these host lineage-specific amino acids in the pathogenicity of H5N1 avian influenza viruses, we generated mutant viruses possessing signature amino acids in the PB2, PA and NP proteins of human influenza isolates ('human-like amino acids') in the genetic background of an avian H5N1 virus, and tested their pathogenicity in mice. We found that some of these mutants exhibited enhanced pathogenicity in mice, suggesting the involvement of these host lineage-specific amino acids in the pathogenicity of H5N1 avian influenza viruses in mammals.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-10430945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-11369884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-11546875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-11748666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-12034486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-14671130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-15016548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-15507653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-16140756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-16140781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-16208372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-16339318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-16880383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-17030872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-17073083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-17459930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-17652405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-17922570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-19119420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-19194459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-19380727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-19421324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-19423869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-19436701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-19574348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-19672242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-19692471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-2416114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-9065404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20016035-9135141
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/NP protein, Influenza A virus,
http://linkedlifedata.com/resource/pubmed/chemical/PA protein, influenza viruses,
http://linkedlifedata.com/resource/pubmed/chemical/PB2 protein, Influenzavirus A,
http://linkedlifedata.com/resource/pubmed/chemical/RNA Replicase,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Core Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1465-2099
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1284-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20016035-Amino Acids,
pubmed-meshheading:20016035-Animals,
pubmed-meshheading:20016035-Brain,
pubmed-meshheading:20016035-Cell Line,
pubmed-meshheading:20016035-Dogs,
pubmed-meshheading:20016035-Humans,
pubmed-meshheading:20016035-Influenza A Virus, H5N1 Subtype,
pubmed-meshheading:20016035-Lethal Dose 50,
pubmed-meshheading:20016035-Lung,
pubmed-meshheading:20016035-Mice,
pubmed-meshheading:20016035-Mutagenesis, Site-Directed,
pubmed-meshheading:20016035-Nasal Cavity,
pubmed-meshheading:20016035-Orthomyxoviridae Infections,
pubmed-meshheading:20016035-RNA Replicase,
pubmed-meshheading:20016035-RNA-Binding Proteins,
pubmed-meshheading:20016035-Viral Core Proteins,
pubmed-meshheading:20016035-Viral Plaque Assay,
pubmed-meshheading:20016035-Viral Proteins,
pubmed-meshheading:20016035-Virulence
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pubmed:year |
2010
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pubmed:articleTitle |
Role of host-specific amino acids in the pathogenicity of avian H5N1 influenza viruses in mice.
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pubmed:affiliation |
Influenza Research Institute, Department of Pathological Science, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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