Source:http://linkedlifedata.com/resource/pubmed/id/20014942
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2010-5-10
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| pubmed:abstractText |
Some studies have demonstrated that N-cadherin is upregulated in more invasive cancer cell lines and tumors and plays a key role in intercellular adhesion. However, the understanding on the roles N-cadherin plays in esophageal squamous cell carcinoma (ESCC) is still poor. Our data showed that knock-down of N-cadherin in ESCC cell line (EC9706) could arrest cell cycle at G0/G1 phase, induce cell apoptosis, reduce the invasiveness in vitro, and inhibit the tumor formation in vivo. These results suggest that N-cadherin is an important factor in the progression and metastasis of ESCC and N-cadherin may serve as a potential molecular target for biotherapy of ESCC.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1532-4192
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
28
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
479-86
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| pubmed:meshHeading |
pubmed-meshheading:20014942-Animals,
pubmed-meshheading:20014942-Antigens, CD,
pubmed-meshheading:20014942-Apoptosis,
pubmed-meshheading:20014942-Cadherins,
pubmed-meshheading:20014942-Carcinoma, Squamous Cell,
pubmed-meshheading:20014942-Cell Cycle,
pubmed-meshheading:20014942-Cell Line, Tumor,
pubmed-meshheading:20014942-Cell Proliferation,
pubmed-meshheading:20014942-Disease Progression,
pubmed-meshheading:20014942-Down-Regulation,
pubmed-meshheading:20014942-Esophageal Neoplasms,
pubmed-meshheading:20014942-Humans,
pubmed-meshheading:20014942-Matrix Metalloproteinase 9,
pubmed-meshheading:20014942-Mice,
pubmed-meshheading:20014942-Mice, Inbred BALB C,
pubmed-meshheading:20014942-Mice, Nude,
pubmed-meshheading:20014942-Neoplasm Invasiveness,
pubmed-meshheading:20014942-Neoplasm Transplantation
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Downregulation of N-cadherin expression inhibits invasiveness, arrests cell cycle and induces cell apoptosis in esophageal squamous cell carcinoma.
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| pubmed:affiliation |
Department of Oncology, First Affiliated Hospital, Zhengzhou University, Henan Province, P R China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|