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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2009-12-17
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pubmed:abstractText |
A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1520-4804
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pubmed:author |
pubmed-author:ChanWai LingWL,
pubmed-author:ChaoAlexA,
pubmed-author:ChenYen-LiangYL,
pubmed-author:DresslerSigmarS,
pubmed-author:GlickmanJ FraserJF,
pubmed-author:JeyarajDuraiswamy ADA,
pubmed-author:KellerThomas HTH,
pubmed-author:KondreddiRavinder ReddyRR,
pubmed-author:LeeWan YenWY,
pubmed-author:LimJoanne Y HJY,
pubmed-author:MuellerDieterD,
pubmed-author:NgRu HuiRH,
pubmed-author:NilarShahulS,
pubmed-author:NiyomrattanakitPornwarattP,
pubmed-author:ShiPei-YongPY,
pubmed-author:SpankaCarstenC,
pubmed-author:VasudevanSubhash GSG,
pubmed-author:VosholHansH,
pubmed-author:WangGangG,
pubmed-author:WenDayingD,
pubmed-author:YinZhengZ
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7934-7
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pubmed:meshHeading |
pubmed-meshheading:20014868-Anthranilic Acids,
pubmed-meshheading:20014868-Binding Sites,
pubmed-meshheading:20014868-Dengue Virus,
pubmed-meshheading:20014868-Enzyme Inhibitors,
pubmed-meshheading:20014868-Humans,
pubmed-meshheading:20014868-Inhibitory Concentration 50,
pubmed-meshheading:20014868-Models, Molecular,
pubmed-meshheading:20014868-RNA Replicase,
pubmed-meshheading:20014868-Structure-Activity Relationship,
pubmed-meshheading:20014868-Sulfinic Acids
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pubmed:year |
2009
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pubmed:articleTitle |
N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.
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pubmed:affiliation |
Novartis Institute for Tropical Diseases, Chromos, 138670, Singapore.
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pubmed:publicationType |
Journal Article
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