Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-4-8
pubmed:abstractText
Na(+)-dependent nucleoside transport was examined in bovine renal brush-border membrane vesicles. Two separate Na+/nucleoside cotransporters were shown to be present: (1) a system specific for purine nucleosides and uridine, designated as the N1 carrier, and (2) an Na(+)-dependent nucleoside transporter that accepts pyrimidine nucleosides, adenosine and analogues of adenosine, designated as the N2 system. Both systems exhibit a high affinity for nucleosides (apparent Km values approximately 10 microM), are insensitive to inhibition by facilitated-diffusion nucleoside transport inhibitors, are rheogenic and exhibit a high specificity for Na+. Na+ increases the affinity of the influx of guanosine and thymidine, nucleosides that serve as model permeants for the N1 and N2 nucleoside transporters respectively. The Na+/nucleoside coupling stoichiometry is consistent with 1:1 for both carriers.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-1690908, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-2276517, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-2337150, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-2604712, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-2730909, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-2917162, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-3048401, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-3198634, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-3382655, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-3567894, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-3778480, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-3926505, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-4034370, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-4521818, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-6117319, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-6210111, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-6254391, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-6438091, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-6473065, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-6980741, http://linkedlifedata.com/resource/pubmed/commentcorrection/2001243-7186937
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
274 ( Pt 1)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-33
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Multiple sodium-dependent nucleoside transport systems in bovine renal brush-border membrane vesicles.
pubmed:affiliation
Biological Laboratory, University of Kent, Canterbury, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't