Linked Life Data

20011655

Source:http://linkedlifedata.com/resource/pubmed/id/20011655

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-12-16
pubmed:abstractText
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy characterized by severe vomiting, diarrhea, and often failure to thrive in infants. Symptoms typically resolve after the triggering food-derived protein is removed from the diet and recur within few hours after the re-exposure to the causal protein. The diagnosis is based on clinical symptoms and a positive food challenge. In this study, we report a case of FPIES to rice in an 8-month-old boy. We performed a double-blind placebo-controlled food challenge (DBPCFC) to rice and we measured the intracellular T cell expression of interleukin-4 (IL-4); IL-10, and interferon gamma (IFN-gamma) pre-and post-challenge during an acute FPIES reaction and when tolerance to rice had been achieved. For the first time we describe an increase in T cell IL-4 and decrease in IFN-gamma expression after a positive challenge with rice (i.e. rice triggered a FPIES attack) and an increase in T cell IL-10 expression after rice challenge 6 months later after a negative challenge (i.e., the child had acquired tolerance to rice) in an 8 month old with documented FPIES to rice. A Th2 activation associated with high IL-4 levels may contribute to the pathophysiology of the disease. On the other hand, T cell-derived IL-10 may play a role in the acquisition of immunotolerance by regulating the Th1 and Th2 responses.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-10518834, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-10678717, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-10887343, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-11069569, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-11799382, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-12671120, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-12911514, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-15637562, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-16697497, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-18829623, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-19130927, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-19136382, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-19188266, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-4039696, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-568171, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-7560641, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-8194697, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-9155835, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-9536936, http://linkedlifedata.com/resource/pubmed/commentcorrection/20011655-9709708
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1740-2530
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2009
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
679381
pubmed:dateRevised
2010-9-28
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Cytokine expression in CD3+ cells in an infant with food protein-induced enterocolitis syndrome (FPIES): case report.
pubmed:affiliation
Allergy and Clinical Immunology Unit, Department of Pediatrics, Meyer Children Hospital, University of Florence, 50122 Florence, Italy. f.mori@meyer.it
pubmed:publicationType
Journal Article, Case Reports