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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-12-29
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pubmed:abstractText |
We report transgenic mouse models in which three or four reprogramming factors are expressed from a single genomic locus using a drug-inducible transgene. Multiple somatic cell types can be directly reprogrammed to generate induced pluripotent stem cells (iPSCs) by culture in doxycycline. Because reprogramming factors are carried on a single polycistronic construct, the mice can be easily maintained, and the transgene can be easily transferred into other genetic backgrounds.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-15882627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-16400644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-16904174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-17554336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-17554338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-18371336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-18423197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-18594521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-18786420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-18786421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-19109433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-19151700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-19252477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-19252478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-19269371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20010831-20038954
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1548-7105
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
56-9
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pubmed:dateRevised |
2011-7-26
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pubmed:meshHeading |
pubmed-meshheading:20010831-Animals,
pubmed-meshheading:20010831-Cell Dedifferentiation,
pubmed-meshheading:20010831-Cells, Cultured,
pubmed-meshheading:20010831-Doxycycline,
pubmed-meshheading:20010831-Gene Expression Regulation,
pubmed-meshheading:20010831-Genome,
pubmed-meshheading:20010831-Induced Pluripotent Stem Cells,
pubmed-meshheading:20010831-Integrases,
pubmed-meshheading:20010831-Mice,
pubmed-meshheading:20010831-Mice, Transgenic,
pubmed-meshheading:20010831-Mutagenesis, Insertional,
pubmed-meshheading:20010831-Nuclear Reprogramming,
pubmed-meshheading:20010831-Organ Specificity,
pubmed-meshheading:20010831-Recombination, Genetic,
pubmed-meshheading:20010831-Transgenes
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pubmed:year |
2010
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pubmed:articleTitle |
Single-gene transgenic mouse strains for reprogramming adult somatic cells.
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pubmed:affiliation |
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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