Linked Life Data

2000823

Source:http://linkedlifedata.com/resource/pubmed/id/2000823

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pubmed-article:2000823pubmed:abstractTextDoses of beta-carotene for cancer-prevention trials have been chosen based on epidemiologic data. Mechanisms of the putative antineoplastic effects by beta-carotene are unknown but may involve modulation of the immune system. We measured plasma carotenoid concentrations and selected immunologic indices at baseline and at 2 and 4 wk in 50 healthy humans (5 groups of 10 each) ingesting 0, 15, 45, 180, or 300 mg beta-carotene/d for 1 mo in this randomized placebo-controlled, open-label, parallel study. Plasma beta-carotene concentrations were markedly increased by 2 wk and were correlated with dose. Beta-carotene concentrations plateaued between 2 and 4 wk except for the 300-mg group. Thus, we developed a dose-concentration curve to optimize beta-carotene-dose selection to achieve target plasma concentrations. We were unable to identify any effects of beta-carotene ingestion on the immunologic indices studied, but modest increases in high-density-lipoprotein cholesterol were observed in all beta-carotene-treated groups.lld:pubmed
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pubmed-article:2000823pubmed:authorpubmed-author:RyanJ AJAlld:pubmed
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pubmed-article:2000823pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:2000823pubmed:articleTitleBeta-carotene's effects on serum lipoproteins and immunologic indices in humans.lld:pubmed
pubmed-article:2000823pubmed:affiliationUpjohn Research Clinics, Upjohn Company, Kalamazoo, MI 49007.lld:pubmed
pubmed-article:2000823pubmed:publicationTypeJournal Articlelld:pubmed
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