Linked Life Data

20007808

Source:http://linkedlifedata.com/resource/pubmed/id/20007808

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:20007808rdf:typepubmed:Citationlld:pubmed
pubmed-article:20007808lifeskim:mentionsumls-concept:C0087111lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C0026336lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C1332717lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C1706438lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C0272286lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C0085358lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C1704632lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C0205082lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C0871261lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C1413244lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C2698600lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C2911692lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C1706817lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C0205263lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C0591833lld:lifeskim
pubmed-article:20007808lifeskim:mentionsumls-concept:C0332324lld:lifeskim
pubmed-article:20007808pubmed:issue6lld:pubmed
pubmed-article:20007808pubmed:dateCreated2010-2-12lld:pubmed
pubmed-article:20007808pubmed:abstractTextImmune thrombocytopenia (ITP) is a bleeding disorder characterized by antibody-opsonized platelets being prematurely destroyed in the spleen, although some patients with ITP may have a cell-mediated form of thrombocytopenia. Although several animal models of ITP have been developed, few mimic primary chronic ITP nor have any shown cell-mediated platelet destruction. To create this type of model, splenocytes from CD61 knockout mice immunized against CD61(+) platelets were transferred into severe combined immunodeficient (SCID) (CD61(+)) mouse recipients, and their platelet counts and phenotypes were observed. As few as 5 x 10(4) splenocytes induced a significant thrombocytopenia and bleeding mortality (80%) in recipients within 3 weeks after transfer. Depletion of lymphocyte subsets before transfer showed that the splenocyte's ability to induce thrombocytopenia and bleeding completely depended on CD4(+) T helper cells and that both CD19(+) B cell (antibody)- and CD8(+) T cell (cell)-mediated effector mechanisms were responsible. Treatment of the SCID mouse recipients with intravenous gamma-globulins raised platelet counts and completely prevented bleeding mortality induced by antibody-mediated effector mechanisms but did not affect cell-mediated disease. This novel model not only shows both antibody- and cell-mediated ITP and bleeding but also suggests that these 2 effector mechanisms have a differential response to therapy.lld:pubmed
pubmed-article:20007808pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20007808pubmed:languageenglld:pubmed
pubmed-article:20007808pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20007808pubmed:citationSubsetAIMlld:pubmed
pubmed-article:20007808pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20007808pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20007808pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20007808pubmed:statusMEDLINElld:pubmed
pubmed-article:20007808pubmed:monthFeblld:pubmed
pubmed-article:20007808pubmed:issn1528-0020lld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:JungM YMYlld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:KimMichaelMlld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:SempleJohn...lld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:LazarusAlan...lld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:FreedmanJohnJlld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:GarveyM...lld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:ChowLeolaLlld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:SpeckEdwin...lld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:AslamRukhsana...lld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:ChenPingguoPlld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:WebsterMichel...lld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:CridlandNorma...lld:pubmed
pubmed-article:20007808pubmed:authorpubmed-author:SahibKimKlld:pubmed
pubmed-article:20007808pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20007808pubmed:day11lld:pubmed
pubmed-article:20007808pubmed:volume115lld:pubmed
pubmed-article:20007808pubmed:ownerNLMlld:pubmed
pubmed-article:20007808pubmed:authorsCompleteYlld:pubmed
pubmed-article:20007808pubmed:pagination1247-53lld:pubmed
pubmed-article:20007808pubmed:dateRevised2010-6-1lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:meshHeadingpubmed-meshheading:20007808...lld:pubmed
pubmed-article:20007808pubmed:year2010lld:pubmed
pubmed-article:20007808pubmed:articleTitleA murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy.lld:pubmed
pubmed-article:20007808pubmed:affiliationToronto Platelet Immunobiology Group, Toronto, Canada.lld:pubmed
pubmed-article:20007808pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20007808pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:16416entrezgene:pubmedpubmed-article:20007808lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:20007808lld:pubmed