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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3 Pt 1
|
| pubmed:dateCreated |
1991-4-8
|
| pubmed:abstractText |
Flosequinan is a novel quinolone with cardiovascular activity that is likely to be of value in the treatment of both heart failure and hypertension. Data generated from animal studies indicate that flosequinan produces dilatation in both veins and arteries, with little associated reflex tachycardia. The compound shows some positive inotropic effects, but the potency is very species dependent. The mode of action of flosequinan seems to involve intracellular calcium handling.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0002-8703
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
121
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
974-83
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2000776-Animals,
pubmed-meshheading:2000776-Blood Pressure,
pubmed-meshheading:2000776-Dose-Response Relationship, Drug,
pubmed-meshheading:2000776-Heart,
pubmed-meshheading:2000776-Hemodynamics,
pubmed-meshheading:2000776-Kidney,
pubmed-meshheading:2000776-Quinolines,
pubmed-meshheading:2000776-Vasodilator Agents
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Pharmacology of flosequinan.
|
| pubmed:affiliation |
Research Department, Boots Pharmaceuticals, Nottingham, England.
|
| pubmed:publicationType |
Journal Article,
Review
|