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rdf:type |
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lifeskim:mentions |
umls-concept:C0004927,
umls-concept:C0031715,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0034783,
umls-concept:C0066908,
umls-concept:C0205527,
umls-concept:C0392756,
umls-concept:C0442805,
umls-concept:C0521329,
umls-concept:C1538051,
umls-concept:C1711351,
umls-concept:C1879547
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pubmed:issue |
2
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pubmed:dateCreated |
2010-1-18
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pubmed:abstractText |
A previous study from our laboratories showed that a significant reduction in spinal N-methyl-D-aspartate (NMDA) receptor NR1 subunit phosphorylation (pNR1) is associated with the antiallodynic effect produced by intrathecal (IT) injection of the alpha-2 adrenoceptor agonist, clonidine, in neuropathic rats. In this study, we determined whether the spontaneous pain and increased pNR1 expression induced by NMDA injection are reduced by IT injection of either clonidine or the mu-opioid receptor agonist, [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin (DAMGO).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADRA2A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ADRA2C protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Adra2a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Adra2c protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-2 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics,
http://linkedlifedata.com/resource/pubmed/chemical/Clonidine,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/NR1 NMDA receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1526-7598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
622-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20007733-Adrenergic alpha-2 Receptor Antagonists,
pubmed-meshheading:20007733-Adrenergic alpha-Agonists,
pubmed-meshheading:20007733-Analgesics,
pubmed-meshheading:20007733-Animals,
pubmed-meshheading:20007733-Behavior, Animal,
pubmed-meshheading:20007733-Clonidine,
pubmed-meshheading:20007733-Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
pubmed-meshheading:20007733-Immunohistochemistry,
pubmed-meshheading:20007733-Injections, Spinal,
pubmed-meshheading:20007733-Male,
pubmed-meshheading:20007733-N-Methylaspartate,
pubmed-meshheading:20007733-Pain,
pubmed-meshheading:20007733-Phosphorylation,
pubmed-meshheading:20007733-Posterior Horn Cells,
pubmed-meshheading:20007733-Rats,
pubmed-meshheading:20007733-Rats, Sprague-Dawley,
pubmed-meshheading:20007733-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:20007733-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:20007733-Receptors, Opioid, mu
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pubmed:year |
2010
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pubmed:articleTitle |
Activation of spinal alpha-2 adrenoceptors, but not mu-opioid receptors, reduces the intrathecal N-methyl-D-aspartate-induced increase in spinal NR1 subunit phosphorylation and nociceptive behaviors in the rat.
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pubmed:affiliation |
Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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