Source:http://linkedlifedata.com/resource/pubmed/id/20007481
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
49
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| pubmed:dateCreated |
2009-12-16
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| pubmed:abstractText |
Restraint stress produces changes in the sleep pattern that are mainly characterized by a delayed increase in rapid eye movement sleep (REMS) amounts. Because the serotonin (5-HT) and the hypocretin (hcrt) systems that regulate REMS are interconnected, we used mutant mice deficient in the 5-HT transporter (5-HTT(-/-)) to examine the role of 5-HT and hcrt neurotransmissions in the sleep response to stress. In contrast to wild-type mice, restraint stress did not induce a delayed increase in REMS amounts in 5-HTT(-/-) mice, indicating impaired sleep homeostasis in mutants. However, pharmacological blockade of the hcrt type 1 receptor (hcrt-R1) before restraint stress restored the REMS increase in 5-HTT(-/-) mice. In line with this finding, 5-HTT(-/-) mutants displayed after restraint stress higher long-lasting activation of hypothalamic preprohcrt neurons than wild-type mice and elevated levels of the hcrt-1 peptide and the hcrt-R1 mRNA in the anterior raphe area. Thus, hypocretinergic neurotransmission was enhanced by stress in 5-HTT(-/-) mice. Furthermore, in 5-HTT(-/-) but not wild-type mice, hypothalamic levels of the 5-HT metabolite 5-hydroxyindole acetic acid significantly increased after restraint stress, indicating a marked enhancement of serotonergic neurotransmission in mutants. Altogether, our data show that increased serotonergic -and in turn hypocretinergic- neurotransmissions exert an inhibitory influence on stress-induced delayed REMS. We propose that the direct interactions between hcrt neurons in the hypothalamus and 5-HT neurons in the anterior raphe nuclei account, at least in part, for the adaptive sleep-wakefulness regulations triggered by acute stress.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyindoleacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neuropeptide,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/orexin receptors,
http://linkedlifedata.com/resource/pubmed/chemical/orexins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1529-2401
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
9
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
15575-85
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| pubmed:meshHeading |
pubmed-meshheading:20007481-Animals,
pubmed-meshheading:20007481-Homeostasis,
pubmed-meshheading:20007481-Hydroxyindoleacetic Acid,
pubmed-meshheading:20007481-Hypothalamus,
pubmed-meshheading:20007481-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:20007481-Male,
pubmed-meshheading:20007481-Mice,
pubmed-meshheading:20007481-Mice, Inbred Strains,
pubmed-meshheading:20007481-Mice, Knockout,
pubmed-meshheading:20007481-Neurons,
pubmed-meshheading:20007481-Neuropeptides,
pubmed-meshheading:20007481-RNA, Messenger,
pubmed-meshheading:20007481-Raphe Nuclei,
pubmed-meshheading:20007481-Receptors, G-Protein-Coupled,
pubmed-meshheading:20007481-Receptors, Neuropeptide,
pubmed-meshheading:20007481-Restraint, Physical,
pubmed-meshheading:20007481-Serotonin,
pubmed-meshheading:20007481-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:20007481-Sleep,
pubmed-meshheading:20007481-Sleep, REM,
pubmed-meshheading:20007481-Stress, Psychological,
pubmed-meshheading:20007481-Synaptic Transmission
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| pubmed:year |
2009
|
| pubmed:articleTitle |
Altered sleep homeostasis after restraint stress in 5-HTT knock-out male mice: a role for hypocretins.
|
| pubmed:affiliation |
Université Pierre et Marie Curie-Paris 6, Faculté de Médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, Institut Fédératif de Recherche 70 des Neurosciences, Unité Mixte de Recherche S677, F-75013 Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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