|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006812,
umls-concept:C0017968,
umls-concept:C0031327,
umls-concept:C0032105,
umls-concept:C0205210,
umls-concept:C0439849,
umls-concept:C0441889,
umls-concept:C0442027,
umls-concept:C0445223,
umls-concept:C1455513,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C2827666
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2010-2-9
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|
pubmed:abstractText |
To determine the pharmacokinetics of gimatecan, a camptothecin with a lipophilic substitution in position 7, given orally to patients participating in the phase I study.
|
|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1879-0852
|
|
pubmed:author |
pubmed-author:BelloEziaE,
pubmed-author:CarminatiPaoloP,
pubmed-author:CompagnoniAnnaA,
pubmed-author:D'IncalciMaurizioM,
pubmed-author:FrapolliRobertaR,
pubmed-author:LocatelliAlbertaA,
pubmed-author:MarsoniSilviaS,
pubmed-author:PisanoClaudioC,
pubmed-author:RulliElianaE,
pubmed-author:SessaCristianaC,
pubmed-author:ViganòLuciaL,
pubmed-author:ZucchettiMassimoM
|
|
pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
46
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
505-16
|
|
pubmed:meshHeading |
pubmed-meshheading:20007015-Administration, Oral,
pubmed-meshheading:20007015-Adolescent,
pubmed-meshheading:20007015-Adult,
pubmed-meshheading:20007015-Aged,
pubmed-meshheading:20007015-Aged, 80 and over,
pubmed-meshheading:20007015-Animals,
pubmed-meshheading:20007015-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:20007015-Blood Specimen Collection,
pubmed-meshheading:20007015-Camptothecin,
pubmed-meshheading:20007015-Chromatography, High Pressure Liquid,
pubmed-meshheading:20007015-Dose-Response Relationship, Drug,
pubmed-meshheading:20007015-Drug Administration Schedule,
pubmed-meshheading:20007015-Female,
pubmed-meshheading:20007015-Half-Life,
pubmed-meshheading:20007015-Humans,
pubmed-meshheading:20007015-Mice,
pubmed-meshheading:20007015-Mice, Nude,
pubmed-meshheading:20007015-Middle Aged,
pubmed-meshheading:20007015-Orosomucoid,
pubmed-meshheading:20007015-Ovarian Neoplasms,
pubmed-meshheading:20007015-Xenograft Model Antitumor Assays,
pubmed-meshheading:20007015-Young Adult
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Clinical pharmacokinetics of the new oral camptothecin gimatecan: the inter-patient variability is related to alpha1-acid glycoprotein plasma levels.
|
|
pubmed:affiliation |
Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156 Milan, Italy. frapolli@marionegri.it
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|
pubmed:publicationType |
Journal Article,
Clinical Trial, Phase I
|
