Source:http://linkedlifedata.com/resource/pubmed/id/20006657
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2010-2-17
|
| pubmed:abstractText |
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein (MAP) kinase kinase kinase family member, which induces apoptosis in various cells through JNK and p38 MAP kinase cascades. In addition to apoptosis signaling, a number of recent in vitro studies have suggested that ASK1 may play roles in neural function. However, the behavioral significance of ASK1 has remained unclear. Here, we subjected ASK1 (-/-) mice to a battery of behavioral tests and found that they displayed temporary hyperactivity in an open-field test. Activities in the familiar field were normal, indicating that the hyperactivity observed was specific to the novel environment. ASK1 (-/-) mice also exhibited impairment of novelty preference 24h after training and superior performance on the rotarod test. Brain tissue contents of dopamine and 4-dihydroxyphenylacetic acid (DOPAC) were elevated in ASK1 (-/-) mice. Our findings thus demonstrate novel behavioral functions of ASK1, including regulation of locomotor activity, novelty preference, and motor coordination with dopaminergic transmission.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1872-8111
|
| pubmed:author |
pubmed-author:FunatsuTakashiT,
pubmed-author:HashikawaKoichiK,
pubmed-author:IchijoHidenoriH,
pubmed-author:IkegamiDaigoD,
pubmed-author:KumakuraKarenK,
pubmed-author:MatsukiNorioN,
pubmed-author:NaritaMinoruM,
pubmed-author:NoguchiTakuyaT,
pubmed-author:NomuraHiroshiH,
pubmed-author:SuzukiTsutomuT,
pubmed-author:TakedaKohsukeK,
pubmed-author:ToyodaTakeshiT,
pubmed-author:TsunodaMakotoM
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
66
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
313-20
|
| pubmed:dateRevised |
2011-11-2
|
| pubmed:meshHeading |
pubmed-meshheading:20006657-3,4-Dihydroxyphenylacetic Acid,
pubmed-meshheading:20006657-Animals,
pubmed-meshheading:20006657-Brain,
pubmed-meshheading:20006657-Dopamine,
pubmed-meshheading:20006657-Environment,
pubmed-meshheading:20006657-Exploratory Behavior,
pubmed-meshheading:20006657-Fear,
pubmed-meshheading:20006657-Hyperkinesis,
pubmed-meshheading:20006657-MAP Kinase Kinase Kinase 5,
pubmed-meshheading:20006657-Male,
pubmed-meshheading:20006657-Memory,
pubmed-meshheading:20006657-Memory Disorders,
pubmed-meshheading:20006657-Mice,
pubmed-meshheading:20006657-Mice, Inbred C57BL,
pubmed-meshheading:20006657-Mice, Knockout,
pubmed-meshheading:20006657-Motor Activity,
pubmed-meshheading:20006657-Neuropsychological Tests,
pubmed-meshheading:20006657-Time Factors
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice.
|
| pubmed:affiliation |
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|