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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-3-8
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pubmed:abstractText |
A combination of cell intrinsic factors and extracellular signals determine whether mouse embryonic stem cells (ESC) divide, self-renew, and differentiate. Here, we report a new interaction between cell intrinsic aspects of the canonical Wnt/Tcf/beta-catenin signaling pathway and extracellular Lif/Jak/Stat3 stimulation that combines to promote self-renewal and proliferation of ESC. Mutant ESC lacking the Tcf3 transcriptional repressor continue to self-renew in the absence of exogenous Lif and through pharmacological inhibition of Lif/Jak/Stat3 signaling; however, proliferation rates of TCF3-/- ESC were significantly decreased by inhibiting Jak/Stat3 activity. Cell mixing experiments showed that stimulation of Stat3 phosphorylation in TCF3-/- ESC was mediated through secretion of paracrine acting factors, but did not involve elevated Lif or LifR transcription. The new interaction between Wnt and Lif/Jak/Stat3 signaling pathways has potential for new insights into the growth of tumors caused by aberrant activity of Wnt/Tcf/beta-catenin signaling.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-10201908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-10580987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-11057671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-11751639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-12163405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-12717450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-12884234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-14585833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-14668413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-14702635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-16036105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-16751178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-16894029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-17018630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-17849470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-18056981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-18227858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-18347094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-18392048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-18497825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-19092804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-19329995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-19649273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-3143916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-3143917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-8628398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-8756721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-9118222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-9308964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-9697701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006604-9845363
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-tert-butyl-9-fluoro-3,6-dihydro-7H...,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Leukemia Inhibitory Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Lif protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridones,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tcf3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1090-2422
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
316
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1050-60
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pubmed:dateRevised |
2011-7-27
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pubmed:meshHeading |
pubmed-meshheading:20006604-Animals,
pubmed-meshheading:20006604-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:20006604-Benzimidazoles,
pubmed-meshheading:20006604-Cell Line,
pubmed-meshheading:20006604-Cell Proliferation,
pubmed-meshheading:20006604-Embryonic Stem Cells,
pubmed-meshheading:20006604-Janus Kinases,
pubmed-meshheading:20006604-Leukemia Inhibitory Factor,
pubmed-meshheading:20006604-Mice,
pubmed-meshheading:20006604-Mice, Knockout,
pubmed-meshheading:20006604-Phosphorylation,
pubmed-meshheading:20006604-Pyridones,
pubmed-meshheading:20006604-STAT3 Transcription Factor,
pubmed-meshheading:20006604-Signal Transduction,
pubmed-meshheading:20006604-Wnt Proteins,
pubmed-meshheading:20006604-beta Catenin
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pubmed:year |
2010
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pubmed:articleTitle |
Non-cell-autonomous stimulation of stem cell proliferation following ablation of Tcf3.
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pubmed:affiliation |
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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