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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-1-27
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pubmed:abstractText |
It is known that the level of protein-conjugated acrolein in plasma is a good marker of chronic renal failure and brain infarction. Thus, studies were carried out to determine which kinds of plasma proteins are conjugated with acrolein. It was found that acrolein was mainly conjugated with albumin. Tandem mass spectrometry analysis demonstrated that Lys-557 and Lys-560, located at the surface of domain III of albumin, were the major sites conjugated with acrolein. This is the first report to identify the amino acid residues in a protein modified by acrolein in vivo. It was found that conjugation of acrolein with albumin contributed to a decrease in the toxicity of acrolein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1090-2104
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pubmed:author |
pubmed-author:DohmaeNaoshiN,
pubmed-author:HigashiKyoheiK,
pubmed-author:IgarashiKazueiK,
pubmed-author:JinLihuaL,
pubmed-author:KashiwagiKeikoK,
pubmed-author:MachiYoshikiY,
pubmed-author:MasudaAkikoA,
pubmed-author:NishimuraKazuhiroK,
pubmed-author:SuganamiAkikoA,
pubmed-author:SuzukiTakehiroT,
pubmed-author:TamuraYutakaY,
pubmed-author:ToidaToshihikoT,
pubmed-author:TomitoriHideyukiH,
pubmed-author:YoshidaMadokaM
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pubmed:copyrightInfo |
Copyright 2009 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
391
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1234-9
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pubmed:meshHeading |
pubmed-meshheading:20006585-Acrolein,
pubmed-meshheading:20006585-Amino Acid Sequence,
pubmed-meshheading:20006585-Biological Markers,
pubmed-meshheading:20006585-Brain Infarction,
pubmed-meshheading:20006585-Humans,
pubmed-meshheading:20006585-Lysine,
pubmed-meshheading:20006585-Molecular Sequence Data,
pubmed-meshheading:20006585-Oxidative Stress,
pubmed-meshheading:20006585-Protein Structure, Tertiary,
pubmed-meshheading:20006585-Serum Albumin,
pubmed-meshheading:20006585-Tandem Mass Spectrometry
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pubmed:year |
2010
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pubmed:articleTitle |
Identification of acrolein-conjugated protein in plasma of patients with brain infarction.
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pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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