Linked Life Data

20005237

Source:http://linkedlifedata.com/resource/pubmed/id/20005237

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-1-28
pubmed:abstractText
Oxidative stress resulting in excessive generation of ROS is a compelling initiator of DNA damage along with damage to various cellular proteins and other macromolecules. Poly(ADP-ribose) polymerase (PARP) activation in response to DNA damage, stirs an energy-consuming cellular metabolic cycle; culminating into cell death. The present study was designed to determine the effect of combining an antioxidant, Melatonin and a PARP inhibitor, Nicotinamide on the hallmark deficits developing in diabetic neuropathy (DN). Streptozotocin (STZ, 55 mg/kg, i.p.) was administered to induce diabetes. Six weeks post diabetes induction, two week treatment with Melatonin (3 and 10 mg/kg) and Nicotinamide (100 and 300 mg/kg) either alone or in combination was given. Effect of these interventions on the functional, behavioral and biochemical changes caused by hyperglycemia were studied in treated animals. Melatonin and Nicotinamide alone as well as in combination ameliorated the functional deficits along with improvement in pain parameters. The combination also demonstrated an essential reversal of biochemical alterations. Nitrotyrosine and Poly ADP Ribose (PAR) immunopositivity was significantly decreased in sciatic nerve micro-sections of treatment group. The results of this study advocate that simultaneous inhibition of oxidative stress-PARP activation cascade may prove useful for the pharmacotherapy of DN.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1873-7064
pubmed:author
pubmed:copyrightInfo
Copyright 2009 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
585-92
pubmed:meshHeading
pubmed-meshheading:20005237-Animals, pubmed-meshheading:20005237-Antioxidants, pubmed-meshheading:20005237-Blood Glucose, pubmed-meshheading:20005237-Body Weight, pubmed-meshheading:20005237-Diabetic Neuropathies, pubmed-meshheading:20005237-Disease Models, Animal, pubmed-meshheading:20005237-Dose-Response Relationship, Drug, pubmed-meshheading:20005237-Drug Interactions, pubmed-meshheading:20005237-Hyperalgesia, pubmed-meshheading:20005237-Lipid Peroxidation, pubmed-meshheading:20005237-Male, pubmed-meshheading:20005237-Melatonin, pubmed-meshheading:20005237-Neural Conduction, pubmed-meshheading:20005237-Niacinamide, pubmed-meshheading:20005237-Pain Measurement, pubmed-meshheading:20005237-Pain Threshold, pubmed-meshheading:20005237-Poly(ADP-ribose) Polymerases, pubmed-meshheading:20005237-Rats, pubmed-meshheading:20005237-Rats, Sprague-Dawley, pubmed-meshheading:20005237-Regional Blood Flow, pubmed-meshheading:20005237-Sciatic Nerve, pubmed-meshheading:20005237-Streptozocin, pubmed-meshheading:20005237-Tyrosine, pubmed-meshheading:20005237-Vitamin B Complex
pubmed:year
2010
pubmed:articleTitle
Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy.
pubmed:affiliation
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar, Punjab-160062, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't