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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-1-8
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pubmed:abstractText |
Blood pressure (BP) has significant heritability, but the genes responsible remain largely unknown. Single nucleotide polymorphisms (SNPs) at the STK39 locus were recently associated with hypertension by genome-wide association in an Amish population; in vitro data from transient transfection experiments using reporter constructs suggested that altered STK39 expression might mediate the effect. However, other large studies have not implicated STK39 in hypertension. We determined whether reported SNPs influenced STK39 expression in vivo, or were associated with BP in a large British Caucasian cohort.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-10834415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-11040222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-11331618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-11731797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-15499010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-15638833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-15947021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-16263722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-16600993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-16642435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-16738273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-16909391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-17554300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-17566082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-18092945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-18200594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-18391953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-18456100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-18593304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-18633328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-18675980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-18852390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-19116668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-19407144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20003416-19609347
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2350
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:20003416-Adult,
pubmed-meshheading:20003416-Alleles,
pubmed-meshheading:20003416-Blood Pressure,
pubmed-meshheading:20003416-European Continental Ancestry Group,
pubmed-meshheading:20003416-Female,
pubmed-meshheading:20003416-Gene Expression Regulation, Developmental,
pubmed-meshheading:20003416-Gene Frequency,
pubmed-meshheading:20003416-Genome-Wide Association Study,
pubmed-meshheading:20003416-Genotype,
pubmed-meshheading:20003416-Great Britain,
pubmed-meshheading:20003416-Humans,
pubmed-meshheading:20003416-Hypertension,
pubmed-meshheading:20003416-Male,
pubmed-meshheading:20003416-Middle Aged,
pubmed-meshheading:20003416-Polymorphism, Single Nucleotide,
pubmed-meshheading:20003416-Protein-Serine-Threonine Kinases
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pubmed:year |
2009
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pubmed:articleTitle |
STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression.
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pubmed:affiliation |
Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK. mike.cunnington@ncl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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