|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2010-4-27
|
|
pubmed:abstractText |
Orexin/hypocretin peptides are expressed in the lateral hypothalamus and involved in the regulation of autonomic functions, energy homeostasis and arousal states. The sleep disorder narcolepsy, which is characterized by excessive daytime sleepiness and occurrence of sudden rapid eye movement (REM) sleep, is associated with a loss of orexin neurones. Our study investigated the effects of orexins on sleep-wake patterns in a novel transgenic mouse line overexpressing the human prepro-orexin (hPPO) gene under the control of its endogenous promoter.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1748-1716
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
198
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
237-49
|
|
pubmed:meshHeading |
pubmed-meshheading:20003098-Animals,
pubmed-meshheading:20003098-Arousal,
pubmed-meshheading:20003098-Darkness,
pubmed-meshheading:20003098-Electroencephalography,
pubmed-meshheading:20003098-Humans,
pubmed-meshheading:20003098-Hypothalamus,
pubmed-meshheading:20003098-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:20003098-Light,
pubmed-meshheading:20003098-Mice,
pubmed-meshheading:20003098-Mice, Transgenic,
pubmed-meshheading:20003098-Neuropeptides,
pubmed-meshheading:20003098-Polysomnography,
pubmed-meshheading:20003098-Protein Isoforms,
pubmed-meshheading:20003098-Receptors, G-Protein-Coupled,
pubmed-meshheading:20003098-Receptors, Neuropeptide,
pubmed-meshheading:20003098-Sleep,
pubmed-meshheading:20003098-Sleep, REM,
pubmed-meshheading:20003098-Sleep Deprivation,
pubmed-meshheading:20003098-Up-Regulation,
pubmed-meshheading:20003098-Wakefulness
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Characterization of sleep-wake patterns in a novel transgenic mouse line overexpressing human prepro-orexin/hypocretin.
|
|
pubmed:affiliation |
Division of Physiology and Biocenter of Oulu, Department of Biomedicine, University of Oulu, Oulu, Finland.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
