pubmed-article:20002520 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:20002520 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:20002520 | lifeskim:mentions | umls-concept:C0235032 | lld:lifeskim |
pubmed-article:20002520 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
pubmed-article:20002520 | lifeskim:mentions | umls-concept:C0115471 | lld:lifeskim |
pubmed-article:20002520 | lifeskim:mentions | umls-concept:C0170657 | lld:lifeskim |
pubmed-article:20002520 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:20002520 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:20002520 | lifeskim:mentions | umls-concept:C0246932 | lld:lifeskim |
pubmed-article:20002520 | pubmed:issue | 4 | lld:pubmed |
pubmed-article:20002520 | pubmed:dateCreated | 2010-2-9 | lld:pubmed |
pubmed-article:20002520 | pubmed:abstractText | 3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a popular recreational drug used worldwide. This study aimed to determine the effects of this compound on the expression of nerve terminal serotonergic markers in rats. Experiment 1 investigated MDMA-induced changes in levels of the serotonin transporter (SERT) and the vesicular monoamine transporter 2 (VMAT-2) in the hippocampus, a region with sparse dopaminergic innervation, after lesioning noradrenergic input with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4). Adult male Sprague-Dawley rats were administered 100 mg/kg DSP-4 or saline 1 week prior to either an MDMA (10 mg/kg x 4) or saline binge. Two weeks following the binge treatment, the DSP-4/MDMA group unexpectedly showed little change in hippocampal VMAT-2 protein expression compared with DSP-4/Saline controls, despite large reductions in SERT levels in all regions examined in the MDMA-treated animals. Furthermore, animals treated with binge MDMA (Experiment 2) showed a striking decrease in SERT gene expression (and a lesser effect on VMAT-2) measured by quantitative RT-PCR in pooled dorsal and median raphe tissue punches, when compared with saline-treated controls. These results demonstrate that MDMA causes substantial regulatory changes in the expression of serotonergic markers, thus questioning the need to invoke distal axotomy as an explanation of MDMA-related serotonergic deficits. | lld:pubmed |
pubmed-article:20002520 | pubmed:language | eng | lld:pubmed |
pubmed-article:20002520 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20002520 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:20002520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20002520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:20002520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20002520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:20002520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20002520 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:20002520 | pubmed:month | Feb | lld:pubmed |
pubmed-article:20002520 | pubmed:issn | 1471-4159 | lld:pubmed |
pubmed-article:20002520 | pubmed:author | pubmed-author:MeyerJerrold... | lld:pubmed |
pubmed-article:20002520 | pubmed:author | pubmed-author:BiezonskiDomi... | lld:pubmed |
pubmed-article:20002520 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:20002520 | pubmed:volume | 112 | lld:pubmed |
pubmed-article:20002520 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:20002520 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:20002520 | pubmed:pagination | 951-62 | lld:pubmed |
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pubmed-article:20002520 | pubmed:year | 2010 | lld:pubmed |
pubmed-article:20002520 | pubmed:articleTitle | Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity. | lld:pubmed |
pubmed-article:20002520 | pubmed:affiliation | Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts, USA. | lld:pubmed |
pubmed-article:20002520 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:20002520 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
entrez-gene:25553 | entrezgene:pubmed | pubmed-article:20002520 | lld:entrezgene |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20002520 | lld:pubmed |