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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-4-14
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pubmed:abstractText |
2´-Deoxy-5-fluorouridylyl-(5´-5´)-3´-C-ethynylcytidine [5-FdU(5´-5´)ECyd] and 3´-C-ethynylcytidinylyl-(5´->1-O)-2-O-octadecyl-sn-glycerylyl-(3-?->5´)-2´-deoxy-5-fluorouridine [ECyd-lipid-5-FdU] are antitumor active duplex drugs and these heterodinucleoside phosphate analogues could be cleaved in vivo by wide-spread phosphodiesterases into different antitumor active antimetabolites.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1573-0646
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
506-13
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pubmed:meshHeading |
pubmed-meshheading:19997962-Adenosine Triphosphate,
pubmed-meshheading:19997962-Antineoplastic Agents,
pubmed-meshheading:19997962-Cell Death,
pubmed-meshheading:19997962-Cell Line, Tumor,
pubmed-meshheading:19997962-Cell Proliferation,
pubmed-meshheading:19997962-Cytidine,
pubmed-meshheading:19997962-Deoxyuridine,
pubmed-meshheading:19997962-Drug Screening Assays, Antitumor,
pubmed-meshheading:19997962-Drug Synergism,
pubmed-meshheading:19997962-Humans,
pubmed-meshheading:19997962-Metabolic Networks and Pathways,
pubmed-meshheading:19997962-Reference Standards
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pubmed:year |
2011
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pubmed:articleTitle |
ATP chemosensitivity testing of new antitumor duplex drugs linking 3`-C-ethynylycytidine (ECyd) and 2´-deoxy-5-fluorouridine (5-FdU) in comparison to standard cytostatica and combinations thereof.
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pubmed:affiliation |
Medical School, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, 69115, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study
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