|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2010-5-4
|
|
pubmed:abstractText |
An alemtuzumab-based experimental immunosuppressive treatment (IST) regimen was investigated in 35 patients with severe aplastic anaemia (SAA), pure red cell (PRCA) or pure white cell aplasia (PWCA). Alemtuzumab total dose was 73-103 mg s.c., followed by cyclosporine. No serious toxicity due to the regimen was observed. Adverse events were clinically irrelevant; infectious events were rare. The total response rate was 58%, 84% and 100% in SAA, PRCA and PWCA, respectively, with corresponding 6 months cumulative response probabilities of 84%, 84% and 100%. Subcutaneous alemtuzumab is a feasible and sufficiently safe IST regimen for patients suffering from immune-mediated marrow failures.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1365-2141
|
|
pubmed:author |
pubmed-author:BacigalupoAndreaA,
pubmed-author:GuptaVikasV,
pubmed-author:HalterJörgJ,
pubmed-author:KulaginAlexanderA,
pubmed-author:MarshJudithJ,
pubmed-author:MaurySébastienS,
pubmed-author:PasswegJakobJ,
pubmed-author:RisitanoAntonio MariaAM,
pubmed-author:RotoliBrunoB,
pubmed-author:SchrezenmeierHubertH,
pubmed-author:SelleriCarmineC,
pubmed-author:SerioBiancaB,
pubmed-author:SocièGerardG,
pubmed-author:TichelliAndréA,
pubmed-author:TorelliGiovanni FernandoGF,
pubmed-author:Working Party Severe Aplastic Anaemia (WPSAA) of the European Group for...
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
148
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
791-6
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:19995389-Adult,
pubmed-meshheading:19995389-Aged,
pubmed-meshheading:19995389-Aged, 80 and over,
pubmed-meshheading:19995389-Anemia, Aplastic,
pubmed-meshheading:19995389-Antibodies, Monoclonal,
pubmed-meshheading:19995389-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:19995389-Antibodies, Neoplasm,
pubmed-meshheading:19995389-Cyclosporine,
pubmed-meshheading:19995389-Drug Therapy, Combination,
pubmed-meshheading:19995389-Female,
pubmed-meshheading:19995389-Humans,
pubmed-meshheading:19995389-Immunosuppressive Agents,
pubmed-meshheading:19995389-Injections, Subcutaneous,
pubmed-meshheading:19995389-Male,
pubmed-meshheading:19995389-Middle Aged,
pubmed-meshheading:19995389-Pilot Projects,
pubmed-meshheading:19995389-Prospective Studies
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Alemtuzumab is safe and effective as immunosuppressive treatment for aplastic anaemia and single-lineage marrow failure: a pilot study and a survey from the EBMT WPSAA.
|
|
pubmed:affiliation |
Department of Biochemistry and Medical Biotechnologies, Federico II University of Naples, Italy. amrisita@unina.it <amrisita@unina.it>
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial, Phase II
|
