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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-4-10
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pubmed:abstractText |
There is evidence in both murine and human lupus that the production of anti-DNA antibodies may be triggered by environmental antigens. To explore this further, we studied the serum of 10 nonautoimmune individuals immunized with a polyvalent pneumococcal polysaccharide vaccine. All 10 patients showed a rise in the titer of antipneumococcal antibodies bearing an anti-DNA-associated idiotype. The antipneumococcal response was specific as no idiotypic antitetanus antibodies were detected. Furthermore, no anti-DNA antibodies were present in postvaccination sera. The molecular analysis of antipneumococcal and anti-DNA antibodies bearing a common idiotype will help elucidate how foreign antigen might lead to the production of anti-DNA antibodies in susceptible individuals.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-1185733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-2471734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3014041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3088209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3102132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3131767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3301096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3480535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3492514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3493261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3514122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3805725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3874226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3875631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3920343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-3925065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-6187005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-6202791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-6435121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1999497-6980900
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Antinuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Single-Stranded,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Idiotypes,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Tetanus Toxoid
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
842-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1999497-Antibodies, Antinuclear,
pubmed-meshheading:1999497-Antibodies, Bacterial,
pubmed-meshheading:1999497-Antibodies, Monoclonal,
pubmed-meshheading:1999497-Antigens, Bacterial,
pubmed-meshheading:1999497-Bacterial Vaccines,
pubmed-meshheading:1999497-DNA, Single-Stranded,
pubmed-meshheading:1999497-Humans,
pubmed-meshheading:1999497-Immunoglobulin G,
pubmed-meshheading:1999497-Immunoglobulin Idiotypes,
pubmed-meshheading:1999497-Immunoglobulin M,
pubmed-meshheading:1999497-Streptococcus pneumoniae,
pubmed-meshheading:1999497-Tetanus Toxoid
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pubmed:year |
1991
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pubmed:articleTitle |
Antibodies elicited by pneumococcal antigens bear an anti-DNA--associated idiotype.
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pubmed:affiliation |
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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